Varicella

Definition:

Varicella-zoster virus (VZV), also known as human herpes virus 3 (HHV-3), is a human pathogen of the Herpesviridae family that has a double-stranded linear DNA genome. Primary infection usually causes varicella (chickenpox) in children, after which the virus establishes latency in sensory neurons. Subsequent reactivation causes herpes zoster (shingles) in adults.

References:

[1]. Cary Chisholm, et al. Cutaneous infections caused by Herpesviridae: a review. Arch Pathol Lab Med. 2011 Oct;135(10):1357-62. [Content Brief]

[2]. D Gilden, et al. Review: The neurobiology of varicella zoster virus infection. Neuropathol Appl Neurobiol. 2011 Aug;37(5):441-63. [Content Brief]

[3]. D R Harper, et al. Molecular biology of varicella-zoster virus. A review prepared for the UK Advisory Group on Chickenpox. J Infect. 1998 Jan;36 Suppl 1:1-10. [Content Brief]

[4]. Mark Quinlivan, et al. Molecular and therapeutic aspects of varicella-zoster virus infection. Expert Rev Mol Med. 2005 Aug 10;7(15):1-24. [Content Brief]

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