Vesicle-associated membrane protein-associated protein A

Definition:

Binds to OSBPL3, which mediates recruitment of VAPA to plasma membrane sites. The ORP3-VAPA complex stimulates RRAS signaling which in turn attenuates integrin beta-1 (ITGB1) activation at the cell surface. With OSBPL3, may regulate ER morphology. May play a role in vesicle trafficking.

References:

[1]. M L Weir, et al. VAP-A binds promiscuously to both v- and tSNAREs. Biochem Biophys Res Commun. 2001 Aug 24;286(3):616-21. [Content Brief]

[2]. Marion Weber-Boyvat, et al. OSBP-related protein 3 (ORP3) coupling with VAMP-associated protein A regulates R-Ras activity. Exp Cell Res. 2015 Feb 15;331(2):278-91. [Content Brief]

[3]. Markku Lehto, et al. Targeting of OSBP-related protein 3 (ORP3) to endoplasmic reticulum and plasma membrane is controlled by multiple determinants. Exp Cell Res. 2005 Nov 1;310(2):445-62. [Content Brief]

[4]. Shotaro Saita, et al. Promotion of neurite extension by protrudin requires its interaction with vesicle-associated membrane protein-associated protein. J Biol Chem. 2009 May 15;284(20):13766-13777. [Content Brief]

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