Vitamin K epoxide reductase complex subunit 1

Definition:

Involved in vitamin K metabolism. Catalytic subunit of the vitamin K epoxide reductase (VKOR) complex which reduces inactive vitamin K 2,3-epoxide to active vitamin K. Vitamin K is required for the gamma-carboxylation of various proteins, including clotting factors, and is required for normal blood coagulation, but also for normal bone development.

References:

[1]. Simone Rost, et al. Site-directed mutagenesis of coumarin-type anticoagulant-sensitive VKORC1: evidence that highly conserved amino acids define structural requirements for enzymatic activity and inhibition by warfarin. Thromb Haemost. 2005 Oct;94(4):780-6. [Content Brief]

[2]. Mark A Rishavy, et al. Novel insight into the mechanism of the vitamin K oxidoreductase (VKOR): electron relay through Cys43 and Cys51 reduces VKOR to allow vitamin K reduction and facilitation of vitamin K-dependent protein carboxylation. J Biol Chem. 2011 Mar 4;286(9):7267-78. [Content Brief]

[3]. Tao Li, et al. Identification of the gene for vitamin K epoxide reductase. Nature. 2004 Feb 5;427(6974):541-4. [Content Brief]

[4]. Hans-Joachim Pelz, et al. The genetic basis of resistance to anticoagulants in rodents. Genetics. 2005 Aug;170(4):1839-47. [Content Brief]

[5]. Shixuan Liu, et al. Structural basis of antagonizing the vitamin K catalytic cycle for anticoagulation. Science. 2021 Jan 1;371(6524):eabc5667. [Content Brief]

[6]. Simone Rost, et al. Mutations in VKORC1 cause warfarin resistance and multiple coagulation factor deficiency type 2. Nature. 2004 Feb 5;427(6974):537-41. [Content Brief]

[7]. Jian-Ke Tie, et al. Human vitamin K epoxide reductase and its bacterial homologue have different membrane topologies and reaction mechanisms. J Biol Chem. 2012 Oct 5;287(41):33945-55. [Content Brief]

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