Voltage-gated potassium channel subunit beta-1

Definition

Cytoplasmic potassium channel subunit that modulates the characteristics of the channel-forming alpha-subunits. Modulates action potentials via its effect on the pore-forming alpha subunits (By similarity). Promotes expression of the pore-forming alpha subunits at the cell membrane, and thereby increases channel activity (By similarity). Mediates closure of delayed rectifier potassium channels by physically obstructing the pore via its N-terminal domain and increases the speed of channel closure for other family members. Promotes the closure of KCNA1, KCNA2 and KCNA5 channels. Accelerates KCNA4 channel closure. Accelerates the closure of heteromeric channels formed by KCNA1 and KCNA4. Accelerates the closure of heteromeric channels formed by KCNA2, KCNA5 and KCNA6 (By similarity). Isoform KvB1.2 has no effect on KCNA1, KCNA2 or KCNB1. Enhances KCNB1 and KCNB2 channel activity (By similarity). Binds NADPH; this is required for efficient down-regulation of potassium channel activity. Has NADPH-dependent aldoketoreductase activity (By similarity). Oxidation of the bound NADPH strongly decreases N-type inactivation of potassium channel activity (By similarity).

References:

[1]. Tarun Bhalla, et al. Control of human potassium channel inactivation by editing of a small mRNA hairpin. Nat Struct Mol Biol. 2004 Oct;11(10):950-6. [Content Brief]

[2]. S K England, et al. A novel K+ channel beta-subunit (hKv beta 1.3) is produced via alternative mRNA splicing. J Biol Chem. 1995 Dec 1;270(48):28531-4. [Content Brief]

[3]. T Leicher, et al. Structural and functional characterization of human potassium channel subunit beta 1 (KCNA1B). Neuropharmacology. 1996;35(7):787-95. [Content Brief]

[4]. S K England, et al. Characterization of a voltage-gated K+ channel beta subunit expressed in human heart. Proc Natl Acad Sci U S A. 1995 Jul 3;92(14):6309-13. [Content Brief]

[5]. K Majumder, et al. Molecular cloning and functional expression of a novel potassium channel beta-subunit from human atrium. FEBS Lett. 1995 Mar 13;361(1):13-6. [Content Brief]

[6]. E A Accili, et al. Separable effects of human Kvbeta1.2 N- and C-termini on inactivation and expression of human Kv1.4. J Physiol. 1998 Oct 15;512 ( Pt 2)(Pt 2):325-36. [Content Brief]

[7]. Srinivas M Tipparaju, et al. NADPH binding to beta-subunit regulates inactivation of voltage-gated K(+) channels. Biochem Biophys Res Commun. 2007 Jul 27;359(2):269-76. [Content Brief]

[8]. M J Morales, et al. A novel beta subunit increases rate of inactivation of specific voltage-gated potassium channel alpha subunits. J Biol Chem. 1995 Mar 17;270(11):6272-7. [Content Brief]

[9]. Christine P Williams, et al. Modulation of the human Kv1.5 channel by protein kinase C activation: role of the Kvbeta1.2 subunit. J Pharmacol Exp Ther. 2002 Aug;302(2):545-50. [Content Brief]

[10]. K McCormack, et al. Alternative splicing of the human Shaker K+ channel beta 1 gene and functional expression of the beta 2 gene product. FEBS Lett. 1995 Aug 14;370(1-2):32-6. [Content Brief]

[11]. Brooke Maylie, et al. Episodic ataxia type 1 mutations in the human Kv1.1 potassium channel alter hKvbeta 1-induced N-type inactivation. J Neurosci. 2002 Jun 15;22(12):4786-93. [Content Brief]

[12]. Christian J Peters, et al. The molecular basis for the actions of KVbeta1.2 on the opening and closing of the KV1.2 delayed rectifier channel. Channels (Austin). 2009 Sep-Oct;3(5):314-22. [Content Brief]

[13]. Paola Imbrici, et al. Episodic ataxia type 1 mutations in the KCNA1 gene impair the fast inactivation properties of the human potassium channels Kv1.4-1.1/Kvbeta1.1 and Kv1.4-1.1/Kvbeta1.2. Eur J Neurosci. 2006 Dec;24(11):3073-83. [Content Brief]

生物医学辞典

生物医学辞典は、生物学の学術用語と専門データの包括的で専門的なデータベースです。すべての説明は、権威ある書籍や高いＩＦの文献に基づいており、知りたい生物医学用語の正確な説明を得ることができます。

A B C D E F G H I J K L M N O P Q R S T U V W X Y Z #

お名前
メール *

	Sorry, but the email address you supplied was invalid.