WAS/WASL-interacting protein family member 2

Definition:

Plays an active role in the formation of cell surface protrusions downstream of activated PDGFB receptors. Plays an important role in actin-microspike formation through cooperation with WASL. May cooperate with WASP and WASL to induce mobilization and reorganization of the actin filament system.

References:

[1]. Masayoshi Kato, et al. WICH, a novel verprolin homology domain-containing protein that functions cooperatively with N-WASP in actin-microspike formation. Biochem Biophys Res Commun. 2002 Feb 15;291(1):41-7. [Content Brief]

[2]. Pontus Aspenström, et al. The WASP-binding protein WIRE has a role in the regulation of the actin filament system downstream of the platelet-derived growth factor receptor. Exp Cell Res. 2002 Sep 10;279(1):21-33. [Content Brief]

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