Zinc finger protein 462
Definition:
Zinc finger nuclear factor involved in transcription by regulating chromatin structure and organization. Involved in the pluripotency and differentiation of embryonic stem cells by regulating SOX2, POU5F1/OCT4, and NANOG. By binding PBX1, prevents the heterodimerization of PBX1 and HOXA9 and their binding to DNA (By similarity). Regulates neuronal development and neural cell differentiation.
References:
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[1]. Julie Massé, et al. ZFPIP/Zfp462 is involved in P19 cell pluripotency and in their neuronal fate. Exp Cell Res. 2011 Aug 1;317(13):1922-34. [Content Brief]
[2]. Julie Massé, et al. Involvement of ZFPIP/Zfp462 in chromatin integrity and survival of P19 pluripotent cells. Exp Cell Res. 2010 Apr 15;316(7):1190-201. [Content Brief]
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