Zinc finger protein Pegasus

Definition:

Transcriptional repressor that binds the core 5'GNNTGTNG-3' DNA consensus sequence. Involved in megakaryocyte differentiation.

References:

[1]. Claire Lentaigne, et al. Germline mutations in the transcription factor IKZF5 cause thrombocytopenia. Blood. 2019 Dec 5;134(23):2070-2081. [Content Brief]

[2]. J Perdomo, et al. Eos and pegasus, two members of the Ikaros family of proteins with distinct DNA binding activities. J Biol Chem. 2000 Dec 8;275(49):38347-54. [Content Brief]

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