Zinc finger protein PLAG1

Definition:

Transcription factor whose activation results in up-regulation of target genes, such as IGFII, leading to uncontrolled cell proliferation: when overexpressed in cultured cells, higher proliferation rate and transformation are observed. Other target genes such as CRLF1, CRABP2, CRIP2, PIGF are strongly induced in cells with PLAG1 induction. Proto-oncogene whose ectopic expression can trigger the development of pleomorphic adenomas of the salivary gland and lipoblastomas. Overexpression is associated with up-regulation of IGFII, is frequently observed in hepatoblastoma, common primary liver tumor in childhood. Cooperates with CBFB-MYH11, a fusion gene important for myeloid leukemia.

References:

[1]. Marianne L Voz, et al. Microarray screening for target genes of the proto-oncogene PLAG1. Oncogene. 2004 Jan 8;23(1):179-91. [Content Brief]

[2]. Andrea Zatkova, et al. Amplification and overexpression of the IGF2 regulator PLAG1 in hepatoblastoma. Genes Chromosomes Cancer. 2004 Feb;39(2):126-37. [Content Brief]

[3]. Karen Hensen, et al. The tumorigenic diversity of the three PLAG family members is associated with different DNA binding capacities. Cancer Res. 2002 Mar 1;62(5):1510-7. [Content Brief]

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