Zinc phosphodiesterase ELAC protein 2

Definition:

Zinc phosphodiesterase, which displays mitochondrial tRNA 3'-processing endonuclease activity. Involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA. Associates with mitochondrial DNA complexes at the nucleoids to initiate RNA processing and ribosome assembly.

References:

[1]. Lien K Brzezniak, et al. Involvement of human ELAC2 gene product in 3' end processing of mitochondrial tRNAs. RNA Biol. 2011 Jul-Aug;8(4):616-26. [Content Brief]

[2]. Daniel F Bogenhagen, et al. Initial steps in RNA processing and ribosome assembly occur at mitochondrial DNA nucleoids. Cell Metab. 2014 Apr 1;19(4):618-29. [Content Brief]

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