2. Gene
  3. Nfkb1 - nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105 Gene

Nfkb1 - nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105 Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Mus musculus

Also known as p50; p105; NF-KB1; p50/p105; NF-kappaB; NF-kappaB1

Gene ID: 18033 | Gene type: protein coding

About Nfkb1

Chromosome 3: 135,290,416-135,397,308 reverse strand.GRCm39:CM000996.3

This gene has 10 transcripts (splice variants), 204 orthologues, 4 paralogues and is associated with 111 phenotypes. Ubiquitous expression in spleen adult (RPKM 34.6), lung adult (RPKM 23.6) and 28 other tissues.

Summary

Enables RNA polymerase II cis-regulatory region sequence-specific DNA binding activity; chromatin binding activity; and identical protein binding activity. Involved in JNK cascade; cellular response to virus; and negative regulation of cytokine production. Acts upstream of or within several processes, including cellular response to dsRNA; cellular response to tumor necrosis factor; and regulation of gene expression. Located in cytosol and nucleus. Is expressed in several structures, including alimentary system; genitourinary system; nervous system; nose; and respiratory system. Human ortholog(s) of this gene implicated in several diseases, including carcinoma (multiple); common variable immunodeficiency; melanoma; prostate cancer; and tropical spastic paraparesis. Orthologous to human NFKB1 (nuclear factor kappa B subunit 1). [provided by Alliance of Genome Resources, Apr 2022]

Nfkb1 Products(2)

mRNA Protein Name
NM_008689.3 NP_032715.2 nuclear factor NF-kappa-B p105 subunit isoform 1
NM_001410442.1 NP_001397371.1 nuclear factor NF-kappa-B p105 subunit isoform 2

Nfkb1 Protein Structure

RHD-n_NFkB1

RHD-n_NFkB1: cd07935 (39 - 240)

IPT_NFkappaB

IPT_NFkappaB: cd01177 (247 - 348)

Ank_2

Ank_2: pfam12796 (533 - 607)

ANK

ANK: sd00045 (537 - 574)

ANK

ANK: sd00045 (576 - 607)

Ank_2

Ank_2: pfam12796 (581 - 675)

ANK

ANK: sd00045 (645 - 676)

Ank_2

Ank_2: pfam12796 (650 - 726)

ANK

ANK: sd00045 (679 - 711)

Death_NFkB1_p105

Death_NFkB1_p105: cd08797 (811 - 885)

  • 0
  • 200
  • 400
  • 600
  • 800
  • 971 a.a.
Protein Preferred Names Protein Names

nuclear factor NF-kappa-B p105 subunit

DNA-binding factor KBF1

EBP-1

NF kappaB1

NF-kappa-B1 p84/NF-kappa-B1 p98

NF-kappaB p50

nuclear factor kappaB p50

nuclear factor of kappa light chain gene enhancer in B-cells 1, p105

p50 subunit of NF kappaB

Related Agents

Pre-clinical Phase
Bioactive Molecules (6)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-133987 AP-1/NF-κB activation inhibitor 1 Inhibitor 99.03% Unkown
HY-49444 EN450 Degrader 99.28% Unkown
HY-N0001S (±)-Epicatechin-13C3 / Unkown
HY-RS09254 NFKB1 Human Pre-designed siRNA Set A / Unkown
HY-RS09255 Nfkb1 Mouse Pre-designed siRNA Set A / Unkown
HY-RS09256 Nfkb1 Rat Pre-designed siRNA Set A / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Nfkb1 NCBI NCBI:4790