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Nfkb1 - nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105 Gene

Also Known as p50; p105; NF-KB1; p50/p105; NF-kappaB; NF-kappaB1

Species: Mus musculus

Gene Type: protein coding

Gene ID: 18033

About Nfkb1

Chromosome 3: 135,290,416-135,397,308 reverse strand.GRCm39:CM000996.3

This gene has 10 transcripts (splice variants), 204 orthologues, 4 paralogues and is associated with 111 phenotypes. Ubiquitous expression in spleen adult (RPKM 34.6), lung adult (RPKM 23.6) and 28 other tissues.

Summary

Enables RNA polymerase II cis-regulatory region sequence-specific DNA binding activity; chromatin binding activity; and identical protein binding activity. Involved in JNK cascade; cellular response to virus; and negative regulation of cytokine production. Acts upstream of or within several processes, including cellular response to dsRNA; cellular response to tumor necrosis factor; and regulation of gene expression. Located in cytosol and nucleus. Is expressed in several structures, including alimentary system; genitourinary system; nervous system; nose; and respiratory system. Human ortholog(s) of this gene implicated in several diseases, including carcinoma (multiple); common variable immunodeficiency; melanoma; prostate cancer; and tropical spastic paraparesis. Orthologous to human NFKB1 (nuclear factor kappa B subunit 1). [provided by Alliance of Genome Resources, Apr 2022]

Nfkb1 Products (2)

mRNA	Protein	Name
NM_008689.3	NP_032715.2	nuclear factor NF-kappa-B p105 subunit isoform 1
NM_001410442.1	NP_001397371.1	nuclear factor NF-kappa-B p105 subunit isoform 2

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables DNA binding	IDA IDA: Inferred from direct assay	10395695	MGI
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IDA IDA: Inferred from direct assay	15845452	MGI
enables chromatin binding	IDA IDA: Inferred from direct assay	20442316	MGI
enables identical protein binding	IPI IPI: Inferred from physical interaction	15220916	MGI
enables protein binding	IPI IPI: Inferred from physical interaction	9556555	MGI
enables sequence-specific DNA binding	IDA IDA: Inferred from direct assay	19404405	MGI
enables transcription coregulator activity	IDA IDA: Inferred from direct assay	15618216	MGI

Biological Process GO Annotation	Evidence	References	Source
involved in B cell receptor signaling pathway	IDA IDA: Inferred from direct assay	17367755	MGI
involved in JNK cascade	IMP IMP: Inferred from mutant phenotype	18802055	MGI
involved in MAPK cascade	IMP IMP: Inferred from mutant phenotype	18802055	MGI
acts upstream of or within cellular response to dsRNA	IMP IMP: Inferred from mutant phenotype	24114535	MGI
involved in cellular response to interleukin-17	IDA IDA: Inferred from direct assay	31164412	MGI
involved in cellular response to lipopolysaccharide	IDA IDA: Inferred from direct assay	31786261	MGI
acts upstream of or within cellular response to tumor necrosis factor	IDA IDA: Inferred from direct assay	24349514	MGI
involved in cellular response to virus	IMP IMP: Inferred from mutant phenotype	18802055	MGI
involved in chemokine production	IMP IMP: Inferred from mutant phenotype	32144162	MGI
involved in cytokine production	IMP IMP: Inferred from mutant phenotype	32144162	MGI
involved in gene expression	IMP IMP: Inferred from mutant phenotype	31623059	MGI
involved in mammary gland involution	IDA IDA: Inferred from direct assay	22555453	MGI
acts upstream of or within negative regulation of DNA-templated transcription	IDA IDA: Inferred from direct assay	14568984	MGI
involved in negative regulation of cytokine production	IMP IMP: Inferred from mutant phenotype	18566389	MGI
acts upstream of or within negative regulation of inflammatory response	IMP IMP: Inferred from mutant phenotype	18270204	MGI
acts upstream of or within negative regulation of interleukin-12 production	IDA IDA: Inferred from direct assay	14568984	MGI
acts upstream of or within positive regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	16081776	MGI
acts upstream of or within positive regulation of transcription by RNA polymerase II	IMP IMP: Inferred from mutant phenotype	15728238	MGI
involved in positive regulation of transcription by RNA polymerase II	IMP IMP: Inferred from mutant phenotype	18802055	MGI
involved in positive regulation of transcription initiation by RNA polymerase II	IMP IMP: Inferred from mutant phenotype	16322095	MGI
acts upstream of or within response to muscle stretch	IDA IDA: Inferred from direct assay	20442316	MGI

Cellular Component GO Annotation	Evidence	References	Source
part of NF-kappaB p50/p65 complex	IDA IDA: Inferred from direct assay	2001591	MGI
located in cytoplasm	IDA IDA: Inferred from direct assay	20060382	MGI
located in cytosol	IDA IDA: Inferred from direct assay	11931770	MGI
is active in nucleus	IDA IDA: Inferred from direct assay	32144162	MGI
located in nucleus	IDA IDA: Inferred from direct assay	10395695	MGI
part of transcription regulator complex	IDA IDA: Inferred from direct assay	2001591	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Nfkb1 Protein Structure

RHD-n_NFkB1

IPT_NFkappaB

Ank_2

ANK

Ank_2

ANK

Ank_2

ANK

Death_NFkB1_p105

0
200
400
600
800
971 a.a.

Protein Preferred Names	Protein Names
nuclear factor NF-kappa-B p105 subunit	DNA-binding factor KBF1 EBP-1 NF kappaB1 NF-kappa-B1 p84/NF-kappa-B1 p98 NF-kappaB p50 nuclear factor kappaB p50 nuclear factor of kappa light chain gene enhancer in B-cells 1, p105 p50 subunit of NF kappaB

Related Agents

Approval
Pre-clinical Phase

Approval

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-19696B	Tauroursodeoxycholate dihydrate		99.96%	Yes

Inhibitory Antibodies (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-P9928	Alirocumab	Inhibitor	97.00%	Unkown

Pre-clinical Phase

Bioactive Molecules (21)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-N0535	(+)-Magnoflorine chloride		99.29%	Unkown
HY-N7922	Urolithin M5	Inhibitor	97.31%	Unkown
HY-133987	AP-1/NF-κB activation inhibitor 1	Inhibitor	98.08%	Unkown
HY-152177	JS6	Inhibitor	99.49%	Unkown
HY-N0334A	(+)-Magnoflorine iodide		99.74%	Unkown
HY-N1508	Ecliptasaponin A		99.81%	Unkown
HY-49444	EN450	Degrader	98.59%	Unkown
HY-N7627	Regaloside C		99.62%	Unkown
HY-174138	NF-κB degrader 1	Degrader	99.92%	Unkown
HY-N0772	Isomangiferin		99.60%	Unkown
HY-RS09254	NFKB1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-N3532	Cannabisin F	Modulator	96.0%	Unkown
HY-N0334	(+)-Magnoflorine		/	Unkown
HY-180580	SMU-C409		/	Unkown
HY-184654	MR-39		/	Unkown
HY-P5762A	Phoenixin-14 TFA		/	Unkown
HY-RS09255	Nfkb1 Mouse Pre-designed siRNA Set A		/	Unkown
HY-RS09256	Nfkb1 Rat Pre-designed siRNA Set A		/	Unkown
HY-W995241	BPD	Inhibitor	/	Unkown
HY-174569	Human NFKB1 mRNA		/	Unkown
HY-N15315	Triptriolide		/	Unkown

Inhibitory Antibodies (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-P9928A	Alirocumab (anti-PCSK9)	Inhibitor	98.24%	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Nfkb1	NCBI	NCBI:4790