ALDH1B1 - aldehyde dehydrogenase 1 family member B1 Gene

Homo sapiens

Also known as ALDH5; ALDHX

Gene ID: 219 | Gene type: protein coding

About ALDH1B1

Cytogenetic location: 9p13.1 Genomic coordinates (GRCh38): 9:38,392,702-38,398,661 (from NCBI)

This gene has 2 transcripts (splice variants), 290 orthologues and 17 paralogues. Broad expression in liver (RPKM 58.4), kidney (RPKM 38.9) and 19 other tissues.

Summary

This protein belongs to the aldehyde dehydrogenases family of proteins. Aldehyde dehydrogenase is the second Enzyme of the major oxidative pathway of alcohol metabolism. This gene does not contain introns in the coding sequence. The variation of this locus may affect the development of alcohol-related problems. [provided by RefSeq, Jul 2008]

ALDH1B1 Products(1)

mRNA	Protein	Name
NM_000692.5	NP_000683.3	aldehyde dehydrogenase X, mitochondrial precursor

ALDH1B1 Protein Structure

Aldedh

0
100
200
300
400
517 a.a.

Protein Preferred Names

Protein Names

aldehyde dehydrogenase X, mitochondrial

ALDH class 2

Related Diseases

Diseases

Alias

Gamma-Amino Butyric Acid Metabolism Disorder

Disorder Of Gamma-Aminobutyric Acid Metabolism	Disorder Of Gaba Metabolism
Disorders Of Gaba - [Gamma Aminobutyric Acid] Metabolism

Succinic Semialdehyde Dehydrogenase Deficiency

4-Hydroxybutyric Aciduria	Ssadh Deficiency
Gamma-Hydroxybutyric Aciduria	Gaba Metabolic Defect
SSADHD	Ssadh
Succinate-Semialdehyde Dehydrogenase Deficiency	Gamma-Hydroxybutyricaciduria
4-Hydroxybutyricaciduria	Gamma-Hydroxybutyric Acidemia
Succinate Semialdehyde Dehydrogenase Deficiency

Hyperprolinemia

Proline Oxidase Deficiency	Hyperprolinemia Type 1
Proline Hydrogenase Deficiency	Prolinemia
Pyrroline Carboxylate Dehydrogenase Deficiency	Pyrroline-5-Carboxylate Dehydrogenase Deficiency
Proline Dehydrogenase Deficiency	Hyperprolinemia Type 2

Sjogren-Larsson Syndrome

Sjögren-Larsson Syndrome	SLS
Faldh Deficiency	Fatty Aldehyde Dehydrogenase Deficiency
Fatty Acid Alcohol Oxidoreductase Deficiency	Ichthyosis, Spastic Neurologic Disorder, And Oligophrenia
Sjogren Larsson Syndrome	Fatty Alcohol:Nad+ Oxidoreductase Deficiency
Sjogren-Larsson'S Syndrome	Fadh Deficiency
Fao Deficiency	Congenital Icthyosis Mental Retardation Spasticity Syndrome
Ichthyosis Oligophrenia Syndrome	Sjoegren-Larsson Syndrome

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-148466	IGUANA-1	Inhibitor	98.88%	Unkown
HY-148243	IGUANA-1 free base	Inhibitor	/	Unkown
HY-RS00565	ALDH1B1 Human Pre-designed siRNA Set A		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Macaca mulatta	ALDH1B1	VGNC	VGNC:81354
Rattus norvegicus	ALDH1B1	RGD	RGD:1306737
Mus musculus	ALDH1B1	MGD	MGI:1919785
Felis catus	ALDH1B1	VGNC	VGNC:102898
Bos taurus	ALDH1B1	VGNC	VGNC:25810
Canis familiaris	ALDH1B1	VGNC	VGNC:51696

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