P2RY11 - purinergic receptor P2Y11 Gene

Homo sapiens

Also known as P2Y11

Gene ID: 5032 | Gene type: protein coding

About P2RY11

Cytogenetic location: 19p13.2 Genomic coordinates (GRCh38): 19:10,111,693-10,115,372 (from NCBI)

This gene has 2 transcripts (splice variants), 145 orthologues, 7 paralogues and is associated with 1 phenotype. Ubiquitous expression in spleen (RPKM 6.0), lymph node (RPKM 4.7) and 25 other tissues.

Summary

The product of this gene belongs to the family of G-protein coupled receptors. This family has several receptor subtypes with different pharmacological selectivity, which overlaps in some cases, for various adenosine and uridine nucleotides. This receptor is coupled to the stimulation of the phosphoinositide and adenylyl cyclase pathways and behaves as a selective purinoceptor. Naturally occuring read-through transcripts, resulting from intergenic splicing between this gene and an immediately upstream gene (PPAN, encoding peter pan homolog), have been found. The PPAN-P2RY11 read-through mRNA is ubiquitously expressed and encodes a fusion protein that shares identity with each individual gene product. [provided by RefSeq, Jul 2008]

P2RY11 Products(1)

mRNA	Protein	Name
NM_002566.5	NP_002557.2	P2Y purinoceptor 11

P2RY11 Protein Structure

7tm_1

0
100
200
300
374 a.a.

Protein Preferred Names

Protein Names

P2Y purinoceptor 11

purinergic receptor P2Y, G-protein coupled, 11

Related Diseases

Diseases

Alias

Recurrent Hypersomnia

Primary Recurrent Hypersomnia	Hypersomnia Recurrent
Disorders Of Excessive Somnolence	Hypersomnia, Recurrent

Narcolepsy 1

NRCLP1	Narcoleptic Syndrome 1
Gelineau Disease	Narcolepsy-Cataplexy
Narcolepsy-Cataplexy Syndrome	Narcolepsy, Type 1
Narcolepsy Type 1	Cataplexy
Gélineau'S Syndrome	Narcolepsy With Cataplexy And/Or Hypocretin Deficiency

Narcolepsy

Paroxysmal Sleep	Gelineau Syndrome
Narcoleptic Syndrome	Narcolepsy-Cataplexy Syndrome
Cataplexy And Narcolepsy	Narcolepsy, Without Cataplexy
Gelineau'S Syndrome	Narcolepsy With Or Without Cataplexy
Narcolepsy Nos

Kleine-Levin Hibernation Syndrome

Kleine-Levin Syndrome	Familial Kleine-Levin Syndrome
Kleine Levin Syndrome	Familial Hibernation Syndrome
Recurrent Hypersomnolence	Hypersomnia-Bulimia Syndrome

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS09918	P2RY11 Human Pre-designed siRNA Set A		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	P2RY11	VGNC	VGNC:106855
Canis familiaris	P2RY11	VGNC	VGNC:108251
Rattus norvegicus	P2RY11	RGD	RGD:7666983

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