PPP1R3A - protein phosphatase 1 regulatory subunit 3A Gene

Homo sapiens

Also known as GM; PP1G; PPP1R3

Gene ID: 5506 | Gene type: protein coding

About PPP1R3A

Cytogenetic location: 7q31.1 Genomic coordinates (GRCh38): 7:113,876,777-113,919,009 (from NCBI)

This gene has 3 transcripts (splice variants), 268 orthologues, 6 paralogues and is associated with 1 phenotype. Restricted expression toward heart (RPKM 17.3).

Summary

The glycogen-associated form of protein phosphatase-1 (PP1) derived from skeletal muscle is a heterodimer composed of a 37-kD catalytic subunit and a 124-kD targeting and regulatory subunit. This gene encodes the regulatory subunit which binds to muscle glycogen with high affinity, thereby enhancing dephosphorylation of glycogen-bound substrates for PP1 such as glycogen synthase and glycogen phosphorylase kinase. [provided by RefSeq, Jul 2008]

PPP1R3A Products(1)

mRNA	Protein	Name
NM_002711.4	NP_002702.2	protein phosphatase 1 regulatory subunit 3A

PPP1R3A Protein Structure

CBM_21

0
200
400
600
800
1000
1122 a.a.

Protein Preferred Names

Protein Names

protein phosphatase 1 regulatory subunit 3A

RG1

Related Diseases

Diseases

Alias

Type 2 Diabetes Mellitus

Insulin Resistance	NIDDM
Type 2 Diabetes	Diabetes Mellitus, Non-Insulin-Dependent
T2D	Noninsulin-Dependent Diabetes Mellitus
Diabetes Mellitus, Type Ii	Maturity-Onset Diabetes
Insulin Resistance, Severe, Digenic	Diabetes Mellitus, Type 2
Diabetes Mellitus, Noninsulin-Dependent	Diabetes Mellitus, Noninsulin-Dependent, Association With
Diabetes Mellitus, Noninsulin-Dependent, Late Onset	Hypertension, Insulin Resistance-Related, Susceptibility To
Insulin Resistance, Susceptibility To	Non-Insulin-Dependent Diabetes Mellitus
Type Ii Diabetes Mellitus	Adult-Onset Diabetes Mellitus
Maturity-Onset Diabetes Mellitus	Diabetes Mellitus Type 2
Type Ii Diabetes	Type 2 Diabetes Mellitus, Susceptibility To
Diabetes, Type 2	Diabetes Mellitus, Noninsulin-Dependent, Susceptibility To
Diabetes Mellitus, Non-Insulin-Dependent, Susceptibility To	Diabetes Mellitus, Type 2, Susceptibility To
Diabetes Mellitus, Noninsulin-Dependent, 2	Diabetes Mellitus, Type Ii, Susceptibility To
Hypertension, Insulin Resistance-Related	Adult-Onset Diabetes
Aodm	Diabetes Mellitus, Adult-Onset
Diabetes Mellitus Type Ii	Diabetes Mellitus Type 2, Susceptibility To
Diabetes, Type Ii, Susceptibility To	Diabetes Type 2
Diabetes Mellitus	Adult Onset Diabetes
Maturity Onset Diabetes	Nonketotic Diabetes
Non-Insulin Dependent Diabetes Mellitus	T2dm - [Type 2 Diabetes Mellitus]
Niddm - [Non Insulin Dependent Diabetes Mellitus]	Dm2
Dm Type Ii	Diabetic Type 2
Insulin Requiring Type 2 Diabetes	Noninsulin Dependent Diabetes
Non-Insulin-Dependent Diabetes Mellitus Without Complications	Diabetes Due To Insulin Secretory Defect
Diabetes Mellitus Due To Insulin Secretory Defect	Non-Insulin-Dependent Diabetes Of The Young
Senile Diabetes	Nonketotic Hyperglycaemia
Stable Diabetes

Diabetes Mellitus

Diabetes

Lipodystrophy, Familial Partial, Type 3

FPLD3	Pparg-Related Familial Partial Lipodystrophy
Familial Partial Lipodystrophy Type 3	Familial Partial Lipodystrophy Associated With Pparg Mutations
Pparg-Related Fpld	Lipodystrophy, Familial Partial, Associated With Pparg Mutations
Insulin Resistance, Severe, Digenic	Lipodystrophy, Familial Partial, 3
Familial Partial Lipodystrophy, Type 3

Glycogen Storage Disease Vi

Glycogen Storage Disease Type Vi	Hers Disease
GSD6	Gsd Vi
Hepatic Glycogen Phosphorylase Deficiency	Phosphorylase Deficiency Glycogen-Storage Disease Of Liver
Hers' Disease	Glycogen Storage Disease Type 6
Glycogen Storage Disease 6	Gsd Type Vi
Glycogenosis Type Vi	Glycogen Storage Disease, Type Vi
Hepatophosphorylase Deficiency Glycogenosis	Liver Phosphorylase Deficiency Syndrome
Glycogen Storage Disease Due To Liver Glycogen Phosphorylase Deficiency	Gsd Due To Liver Glycogen Phosphorylase Deficiency
Gsd Type 6	Glycogenosis Due To Liver Glycogen Phosphorylase Deficiency
Glycogenosis Type 6	Hepatic Phosphorylase Deficiency
Liver Glycogen Phosphorylase Deficiency	Her
Glycogen Storage Disease Vib	Gsd-Vi
Liver Phosphorylase Deficiency	Storage Disease, Glycogen, Type Vi

Prediabetes Syndrome

Prediabetes	Impaired Glucose Tolerance
Prediabetic State	IGT
Igt - [Impaired Glucose Tolerance]	Impaired Glucose Tolerance With Unspecified Complication
Impaired Glucose Tolerance Without Complication	Abnormal Glucose Tolerance

Myoclonic Epilepsy Of Lafora

Lafora Disease	Epilepsy, Progressive Myoclonic 2b
EPM2	Melf
Epilepsy, Progressive Myoclonic 2a	Epm2a
Lafora'S Disease	Lafora Body Disease
Lbd	Epilepsy, Progressive Myoclonic, 2a
Lafora Progressive Myoclonic Epilepsy	Epilepsy Progressive Myoclonic 2
Lafora Body Disorder	Pme Type 2
Progressive Myoclonic Epilepsy Type 2	Progressive Myoclonus Epilepsy Type 2
Epilepsy, Progressive Myoclonic 2	Epm2b
Ld	Progressive Myoclonic Epilepsy 2
Progressive Myoclonic Epilepsy 2a	Progressive Myoclonic Epilepsy 2b
Progressive Myoclonic Epilepsy Lafora Type	Epilepsy, Myoclonic, Of Lafora

Congenital Generalized Lipodystrophy

Berardinelli-Seip Congenital Lipodystrophy	Berardinelli-Seip Syndrome
Brunzell Syndrome	Bscl
Generalized Lipodystrophy	Lipodystrophy, Congenital Generalized
Seip Syndrome	Total Lipodystrophy
Cgl	Lipoatrophic Diabetes
Lipodystrophy, Generalized, Congenital	Familial Generalized Lipodystrophy
Congenital Generalized Lipodystrophy Type 2	Lipoatrophic Diabetes Mellitus
Familial Partial Lipodystrophy, Type 2

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS10998	PPP1R3A Human Pre-designed siRNA Set A		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Felis catus	PPP1R3A	VGNC	VGNC:69003
Mus musculus	PPP1R3A	MGD	MGI:2153588
Canis familiaris	PPP1R3A	VGNC	VGNC:44896
Bos taurus	PPP1R3A	VGNC	VGNC:33242
Macaca mulatta	PPP1R3A	VGNC	VGNC:81744
Rattus norvegicus	PPP1R3A	RGD	RGD:1561312

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