PPP1R3A - protein phosphatase 1 regulatory subunit 3A Gene

Also Known as GM; PP1G; PPP1R3

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 5506

About PPP1R3A

Cytogenetic location: 7q31.1 Genomic coordinates (GRCh38): 7:113,876,777-113,919,009 (from NCBI)

This gene has 3 transcripts (splice variants), 268 orthologues, 6 paralogues and is associated with 1 phenotype. Restricted expression toward heart (RPKM 17.3).

Summary

The glycogen-associated form of protein phosphatase-1 (PP1) derived from skeletal muscle is a heterodimer composed of a 37-kD catalytic subunit and a 124-kD targeting and regulatory subunit. This gene encodes the regulatory subunit which binds to muscle glycogen with high affinity, thereby enhancing dephosphorylation of glycogen-bound substrates for PP1 such as glycogen synthase and glycogen Phosphorylase kinase. [provided by RefSeq, Jul 2008]

PPP1R3A Products (1)

mRNA Protein Name
NM_002711.4 NP_002702.2 protein phosphatase 1 regulatory subunit 3A

PPP1R3A Protein Structure

CBM_21

CBM_21: Carbohydrate/starch-binding module (family 21) (124 - 229)

  • 0
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  • 1000
  • 1122 a.a.
Protein Preferred Names Protein Names

protein phosphatase 1 regulatory subunit 3A

  • RG1

Related Diseases

Diseases Alias
Type 2 Diabetes Mellitus

  • Insulin Resistance

  • NIDDM

  • Type 2 Diabetes

  • Diabetes Mellitus, Non-Insulin-Dependent

  • T2D

  • Noninsulin-Dependent Diabetes Mellitus

  • Diabetes Mellitus, Type Ii

  • Maturity-Onset Diabetes

  • Insulin Resistance, Severe, Digenic

  • Diabetes Mellitus, Type 2

  • Diabetes Mellitus, Noninsulin-Dependent

  • Diabetes Mellitus, Noninsulin-Dependent, Association With

  • Diabetes Mellitus, Noninsulin-Dependent, Late Onset

  • Hypertension, Insulin Resistance-Related, Susceptibility To

  • Insulin Resistance, Susceptibility To

  • Non-Insulin-Dependent Diabetes Mellitus

  • Type Ii Diabetes Mellitus

  • Adult-Onset Diabetes Mellitus

  • Maturity-Onset Diabetes Mellitus

  • Diabetes Mellitus Type 2

  • Type Ii Diabetes

  • Type 2 Diabetes Mellitus, Susceptibility To

  • Diabetes, Type 2

  • Diabetes Mellitus, Noninsulin-Dependent, Susceptibility To

  • Diabetes Mellitus, Non-Insulin-Dependent, Susceptibility To

  • Diabetes Mellitus, Type 2, Susceptibility To

  • Diabetes Mellitus, Noninsulin-Dependent, 2

  • Diabetes Mellitus, Type Ii, Susceptibility To

  • Hypertension, Insulin Resistance-Related

  • Adult-Onset Diabetes

  • Aodm

  • Diabetes Mellitus, Adult-Onset

  • Diabetes Mellitus Type Ii

  • Diabetes Mellitus Type 2, Susceptibility To

  • Diabetes, Type Ii, Susceptibility To

  • Diabetes Type 2

  • Diabetes Mellitus

  • Adult Onset Diabetes

  • Maturity Onset Diabetes

  • Nonketotic Diabetes

  • Non-Insulin Dependent Diabetes Mellitus

  • T2dm - [Type 2 Diabetes Mellitus]

  • Niddm - [Non Insulin Dependent Diabetes Mellitus]

  • Dm2

  • Dm Type Ii

  • Diabetic Type 2

  • Insulin Requiring Type 2 Diabetes

  • Noninsulin Dependent Diabetes

  • Non-Insulin-Dependent Diabetes Mellitus Without Complications

  • Diabetes Due To Insulin Secretory Defect

  • Diabetes Mellitus Due To Insulin Secretory Defect

  • Non-Insulin-Dependent Diabetes Of The Young

  • Senile Diabetes

  • Nonketotic Hyperglycaemia

  • Stable Diabetes
Diabetes Mellitus

  • Diabetes
Lipodystrophy, Familial Partial, Type 3

  • FPLD3

  • Pparg-Related Familial Partial Lipodystrophy

  • Familial Partial Lipodystrophy Type 3

  • Familial Partial Lipodystrophy Associated With Pparg Mutations

  • Pparg-Related Fpld

  • Lipodystrophy, Familial Partial, Associated With Pparg Mutations

  • Insulin Resistance, Severe, Digenic

  • Lipodystrophy, Familial Partial, 3

  • Familial Partial Lipodystrophy, Type 3
Glycogen Storage Disease Vi

  • Glycogen Storage Disease Type Vi

  • Hers Disease

  • GSD6

  • Gsd Vi

  • Hepatic Glycogen Phosphorylase Deficiency

  • Phosphorylase Deficiency Glycogen-Storage Disease Of Liver

  • Hers' Disease

  • Glycogen Storage Disease Type 6

  • Glycogen Storage Disease 6

  • Gsd Type Vi

  • Glycogenosis Type Vi

  • Glycogen Storage Disease, Type Vi

  • Hepatophosphorylase Deficiency Glycogenosis

  • Liver Phosphorylase Deficiency Syndrome

  • Glycogen Storage Disease Due To Liver Glycogen Phosphorylase Deficiency

  • Gsd Due To Liver Glycogen Phosphorylase Deficiency

  • Gsd Type 6

  • Glycogenosis Due To Liver Glycogen Phosphorylase Deficiency

  • Glycogenosis Type 6

  • Hepatic Phosphorylase Deficiency

  • Liver Glycogen Phosphorylase Deficiency

  • Her

  • Glycogen Storage Disease Vib

  • Gsd-Vi

  • Liver Phosphorylase Deficiency

  • Storage Disease, Glycogen, Type Vi
Prediabetes Syndrome

  • Prediabetes

  • Impaired Glucose Tolerance

  • Prediabetic State

  • IGT

  • Igt - [Impaired Glucose Tolerance]

  • Impaired Glucose Tolerance With Unspecified Complication

  • Impaired Glucose Tolerance Without Complication

  • Abnormal Glucose Tolerance
Myoclonic Epilepsy Of Lafora

  • Lafora Disease

  • Epilepsy, Progressive Myoclonic 2b

  • EPM2

  • Melf

  • Epilepsy, Progressive Myoclonic 2a

  • Epm2a

  • Lafora'S Disease

  • Lafora Body Disease

  • Lbd

  • Epilepsy, Progressive Myoclonic, 2a

  • Lafora Progressive Myoclonic Epilepsy

  • Epilepsy Progressive Myoclonic 2

  • Lafora Body Disorder

  • Pme Type 2

  • Progressive Myoclonic Epilepsy Type 2

  • Progressive Myoclonus Epilepsy Type 2

  • Epilepsy, Progressive Myoclonic 2

  • Epm2b

  • Ld

  • Progressive Myoclonic Epilepsy 2

  • Progressive Myoclonic Epilepsy 2a

  • Progressive Myoclonic Epilepsy 2b

  • Progressive Myoclonic Epilepsy Lafora Type

  • Epilepsy, Myoclonic, Of Lafora
Congenital Generalized Lipodystrophy

  • Berardinelli-Seip Congenital Lipodystrophy

  • Berardinelli-Seip Syndrome

  • Brunzell Syndrome

  • Bscl

  • Generalized Lipodystrophy

  • Lipodystrophy, Congenital Generalized

  • Seip Syndrome

  • Total Lipodystrophy

  • Cgl

  • Lipoatrophic Diabetes

  • Lipodystrophy, Generalized, Congenital

  • Familial Generalized Lipodystrophy

  • Congenital Generalized Lipodystrophy Type 2

  • Lipoatrophic Diabetes Mellitus

  • Familial Partial Lipodystrophy, Type 2
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS10998 PPP1R3A Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Felis catus PPP1R3A VGNC VGNC:69003
Mus musculus PPP1R3A MGD MGI:2153588
Canis familiaris PPP1R3A VGNC VGNC:44896
Bos taurus PPP1R3A VGNC VGNC:33242
Macaca mulatta PPP1R3A VGNC VGNC:81744
Rattus norvegicus PPP1R3A RGD RGD:1561312
Others PPP1R3A NCBI