Schizophrenia Models
Dizocilpine maleate
Synonyms: (+)-MK 801 Maleate
- Formula: C20H19NO4
- Molecular Weight: 337.37
Dizocilpine maleate (MK-801 maleate) is a potent, selective and non-competitive NMDA receptor antagonist with Kd of 37.2 nM in rat brain membranes.
Dizocilpine
Synonyms: MK-801
- Formula: C16H15N
- Molecular Weight: 221.30
Dizocilpine (MK-801), a potent anticonvulsant, is a selective and non-competitive NMDA receptor antagonist, with a Kd of 37.2 nM in rat brain membranes. Dizocilpine acts by binding to a site located within the NMDA associated ion channel and thus prevents Ca2+ flux.
Cuprizone
Synonyms: CPZ
- Formula: C14H22N4O2
- Molecular Weight: 278.36
Cuprizone is a copper-chelating agent that induces selective mature oligodendrocyte apoptosis and robust demyelination in C57BL/6 mouse brain, widely used as a toxic animal model of multiple sclerosis (MS) for studying de-and remyelination mechanisms.
