1. Epigenetics
    Stem Cell/Wnt
    JAK/STAT Signaling
  2. JAK
  3. JAK-2/3-IN-1

JAK-2/3-IN-1 

Cat. No.: HY-10652
Handling Instructions

JAK-2/3-IN-1 is a potent JAK-2 and JAK-3 inhibitor extracted from patent US8163732B2, compound 46, has Kis of <250 nM for both isoforms.

For research use only. We do not sell to patients.

JAK-2/3-IN-1 Chemical Structure

JAK-2/3-IN-1 Chemical Structure

CAS No. : 1036241-36-7

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Description

JAK-2/3-IN-1 is a potent JAK-2 and JAK-3 inhibitor extracted from patent US8163732B2, compound 46, has Kis of <250 nM for both isoforms[1].

IC50 & Target[1]

JAK2

<250 nM (Ki)

JAK3

<250 nM (Ki)

In Vitro

The Janus kinases (JAK) are a family of tyrosine kinases that play a critical role in cytokine signaling. The family consists of JAK-1, JAK-2, JAK-3 and TYK-2, and the down-stream substrates of this family of kinases include the signal transducer and activator of transcription (STAT) proteins. JAK/STAT signaling has been implicated in the mediation of many abnormal immune responses, such as allergies and asthma; autoimmune diseases; as well as in solid and hematologic malignancies[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

345.78

Formula

C₂₀H₁₂ClN₃O

CAS No.

1036241-36-7

SMILES

OC1=CC=C(C2=NC3=CC=CC=C3C4=C5C(NC=C25)=NC=C4)C(Cl)=C1

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

References
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Keywords:

JAK-2/3-IN-1JAKJanus kinaseJAK-2JAK-3STATInhibitorinhibitorinhibit

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JAK-2/3-IN-1
Cat. No.:
HY-10652
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