2. Epigenetics Stem Cell/Wnt Protein Tyrosine Kinase/RTK JAK/STAT Signaling
  3. JAK
  4. JAK-2/3-IN-1

JAK-2/3-IN-1 is a potent JAK-2 and JAK-3 inhibitor extracted from patent US8163732B2, compound 46, has Kis of <250 nM for both isoforms.

For research use only. We do not sell to patients.

JAK-2/3-IN-1 Chemical Structure

JAK-2/3-IN-1 Chemical Structure

CAS No. : 1036241-36-7

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JAK-2/3-IN-1 Related Antibodies

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Description

JAK-2/3-IN-1 is a potent JAK-2 and JAK-3 inhibitor extracted from patent US8163732B2, compound 46, has Kis of <250 nM for both isoforms[1].

IC50 & Target[1]

JAK2

<250 nM (Ki)

JAK3

<250 nM (Ki)

In Vitro

The Janus kinases (JAK) are a family of tyrosine kinases that play a critical role in cytokine signaling. The family consists of JAK-1, JAK-2, JAK-3 and TYK-2, and the down-stream substrates of this family of kinases include the signal transducer and activator of transcription (STAT) proteins. JAK/STAT signaling has been implicated in the mediation of many abnormal immune responses, such as allergies and asthma; autoimmune diseases; as well as in solid and hematologic malignancies[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

JAK-2/3-IN-1 Related Antibodies
Molecular Weight

345.78

Formula

C20H12ClN3O
CAS No.
SMILES

OC1=CC=C(C2=NC3=CC=CC=C3C4=C5C(NC=C25)=NC=C4)C(Cl)=C1
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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JAK-2/3-IN-1 Related Classifications

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The molarity calculator equation

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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

JAK-2/3-IN-11036241-36-7JAKJanus kinaseJAK-2JAK-3STATInhibitorinhibitorinhibit

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