2. LFF-571

LFF-571 is an orally active semisynthetic thiopeptide antibiotic. LFF-571 shows potent activity against a Clostridium difficile and Staphylococcus aureus with MIC values of 0.03 and 0.125 μg/mL, respectively. LFF-571 can be used for the research of infection.

For research use only. We do not sell to patients.

LFF-571 Chemical Structure

LFF-571 Chemical Structure

CAS No. : 1160959-55-6

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LFF-571 Related Antibodies

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Description

LFF-571 is an orally active semisynthetic thiopeptide antibiotic. LFF-571 shows potent activity against a Clostridium difficile and Staphylococcus aureus with MIC values of 0.03 and 0.125 μg/mL, respectively. LFF-571 can be used for the research of infection[1].

In Vitro

LFF-571 (0-32 μg/mL) shows MIC values of ＜0.06, ＜0.06, 0.125, 1 and 0.03 μg/mL for E. faecails, E. feacium, S. aureus, S. pyogenes and C. difficile, respectively[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

LFF-571 Related Antibodies
In Vivo

LFF-571 (2 and 20 mg/kg; p.o. once daily for 5 days) survives infection hamster[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Golden Syrian hamster with C. difficile infection[1]
Dosage: 2 and 20 mg/kg
Administration: Oral gavage; 2 and 20 mg/kg once daily for 5 days
Result: Showed a dose-dependent effect on survival of infection hamster.
Clinical Trial
Molecular Weight

1366.61

Formula

C60H63N13O13S6
CAS No.
SMILES

O=C1C2=CSC(C3=CC=C(C4=NC(N(CCCCC(O)=O)C(O[C@@H]5CC[C@H](CC5)C(O)=O)=O)=CS4)N=C3C6=CSC(C7=CSC([C@](NC(CNC(C8=C(SC([C@@H](NC(C9=C(C)SC([C@@H](N1)CC(NC)=O)=N9)=O)C(C)C)=N8)COC)=O)=O)([H])[C@H](C%10=CC=CC=C%10)O)=N7)=N6)=N2
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Room temperature in continental US; may vary elsewhere.
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Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

LFF-5711160959-55-6LFF571LFF 571Inhibitorinhibitorinhibit

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