2. Academic Validation
  3. Two auronols from Pseudolarix amabilis

Two auronols from Pseudolarix amabilis

  • J Nat Prod. 1999 May;62(5):767-9. doi: 10.1021/np980469w.
X C Li 1,  H N ElSohly,  A C Nimrod,  A M Clark
Affiliations

Affiliation

  • 1 National Center for the Development of Natural Products, Research Institute of Pharmaceutical Sciences and Department of Pharmacognosy, School of Pharmacy, The University of Mississippi, University, Mississippi 38677, USA.
PMID: 10346966 DOI: 10.1021/np980469w
Abstract

Two new auronols, amaronols A (1) and B (2), were isolated from the bark of Pseudolarix amabilis, along with pseudolaric acid B (3), pseudolaric acid C (4), demethoxydeacetoxy-pseudolaric acid B (5), pseudolaric acid B-beta-D-glucoside (6), pseudolaric acid A-beta-D-glucoside (7), and myricetin (8). The structures of amaronols A and B were established by spectral data interpretation as 2,4,6-trihydroxy-2-[(3',4',5'-trihydroxyphenyl) methyl]-3(2H)-benzofuranone and 2,4,6-trihydroxy-2-[(3', 5'-dihydroxy-4'-methoxyphenyl) methyl]-3(2H)-benzofuranone, respectively. Antimicrobial testing results of the eight compounds indicated that only pseudolaric acid B was active against Candida albicans (MIC, 3.125 microg/mL; MFC, 6.25 microg/mL), while myricetin was marginally active against Trichophyton mentagrophytes (MIC, 50 microg/mL).

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