2. Academic Validation
  3. Depudecin: a novel compound inducing the flat phenotype of NIH3T3 cells doubly transformed by ras- and src-oncogene, produced by Alternaria brassicicola

Depudecin: a novel compound inducing the flat phenotype of NIH3T3 cells doubly transformed by ras- and src-oncogene, produced by Alternaria brassicicola

  • J Antibiot (Tokyo). 1992 Jun;45(6):879-85. doi: 10.7164/antibiotics.45.879.
M Matsumoto 1,  S Matsutani,  K Sugita,  H Yoshida,  F Hayashi,  Y Terui,  H Nakai,  N Uotani,  Y Kawamura,  K Matsumoto
Affiliations

Affiliation

  • 1 Shionogi Research Laboratories, Shionogi & Co., Ltd., Osaka, Japan.
PMID: 1500354 DOI: 10.7164/antibiotics.45.879
Abstract

A novel compound depudecin inducing the flat phenotype of ras- and src- transformed NIH3T3 cells at a concentration of 1 microgram/ml was isolated from the culture broth of Alternaria brassicicola. Based on its spectroscopic characteristics and X-ray crystallographic analysis of its bis-(1S)-(-)-camphanate, the structure of depudecin was determined to be (2R,3S,4S,5E,7S,8S,9R)-2,9- dihydroxy-3,4;7,8-diepoxy-undeca-5,10-diene.

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