DC-SIGN and DC-SIGNR interact with the glycoprotein of Marburg virus and the S protein of severe acute respiratory syndrome coronavirus

  • J Virol. 2004 Nov;78(21):12090-5. doi: 10.1128/JVI.78.21.12090-12095.2004.
Andrea Marzi  1 ,  Thomas Gramberg ,  Graham Simmons ,  Peggy Möller ,  Andrew J Rennekamp ,  Mandy Krumbiegel ,  Martina Geier ,  Jutta Eisemann ,  Nadine Turza ,  Bertrand Saunier ,  Alexander Steinkasserer ,  Stephan Becker ,  Paul Bates ,  Heike Hofmann ,  Stefan Pöhlmann
Affiliations
  • 1. Institute for Clinical and Molecular Virology, University Erlangen-Nürnberg, Nikolaus-Fiebiger-Center, Glückstrasse 6, D-91054 Erlangen, Germany.
PMID: 15479853 DOI: 10.1128/JVI.78.21.12090-12095.2004
Abstract

The lectins DC-SIGN and DC-SIGNR can augment viral infection; however, the range of pathogens interacting with these attachment factors is incompletely defined. Here we show that DC-SIGN and DC-SIGNR enhance Infection mediated by the glycoprotein (GP) of Marburg virus (MARV) and the S protein of severe acute respiratory syndrome coronavirus and might promote viral dissemination. SIGNR1, a murine DC-SIGN homologue, also enhanced Infection driven by MARV and Ebola virus GP and could be targeted to assess the role of attachment factors in Filovirus infection in vivo.