2. Academic Validation
  3. Lariatins, novel anti-mycobacterial peptides with a lasso structure, produced by Rhodococcus jostii K01-B0171

Lariatins, novel anti-mycobacterial peptides with a lasso structure, produced by Rhodococcus jostii K01-B0171

  • J Antibiot (Tokyo). 2007 Jun;60(6):357-63. doi: 10.1038/ja.2007.48.
Masato Iwatsuki 1,  Ryuji Uchida,  Yoichi Takakusagi,  Atsuko Matsumoto,  Cheng-Lin Jiang,  Yoko Takahashi,  Masayoshi Arai,  Susumu Kobayashi,  Makoto Matsumoto,  Junji Inokoshi,  Hiroshi Tomoda,  Satoshi Omura
Affiliations

Affiliation

  • 1 The Kitasato Institute, Shirokane, Tokyo, Japan.
PMID: 17617692 DOI: 10.1038/ja.2007.48
Abstract

Two anti-mycobacterial Peptides with a lasso structure, named lariatins A and B, were separated by HP-20 and ODS column chromatographies and purified by HPLC from the culture broth of Rhodococcus jostii K01-B0171, which was isolated from soil aggregates collected in Yunnan, China. Lariains A and B showed growth inhibition against Mycobacterium smegmatis with MIC values of 3.13 and 6.25 microg/ml in agar dilution method, respectively. Furthermore, lariatin A inhibited the growth of Mycobacterium tuberculosis with an MIC of 0.39 microg/ml in liquid microdilution method.

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