2. Academic Validation
  3. Histone acetyltransferase hALP and nuclear membrane protein hsSUN1 function in de-condensation of mitotic chromosomes

Histone acetyltransferase hALP and nuclear membrane protein hsSUN1 function in de-condensation of mitotic chromosomes

  • J Biol Chem. 2007 Sep 14;282(37):27447-27458. doi: 10.1074/jbc.M703098200.
Ya-Hui Chi 1,  Kerstin Haller 1,  Jean-Marie Peloponese Jr 1,  Kuan-Teh Jeang 2
Affiliations

Affiliations

  • 1 Molecular Virology Section, Laboratory of Molecular Microbiology, NIAID, National Institutes of Health, Bethesda, Maryland 20892.
  • 2 Molecular Virology Section, Laboratory of Molecular Microbiology, NIAID, National Institutes of Health, Bethesda, Maryland 20892. Electronic address: [email protected].
PMID: 17631499 DOI: 10.1074/jbc.M703098200
Abstract

Replicated mammalian chromosomes condense to segregate during anaphase, and they de-condense at the conclusion of mitosis. Currently, it is not understood what the factors and events are that specify de-condensation. Here, we demonstrate that chromosome de-condensation needs the function of an inner nuclear membrane (INM) protein hsSUN1 and a membrane-associated Histone Acetyltransferase (HAT), hALP. We propose that nascently reforming nuclear envelope employs hsSUN1 and hALP to acetylate histones for de-compacting DNA at the end of mitosis.

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