2. Academic Validation
  3. Chemerin enhances insulin signaling and potentiates insulin-stimulated glucose uptake in 3T3-L1 adipocytes

Chemerin enhances insulin signaling and potentiates insulin-stimulated glucose uptake in 3T3-L1 adipocytes

  • FEBS Lett. 2008 Mar 5;582(5):573-8. doi: 10.1016/j.febslet.2008.01.023.
Michiko Takahashi 1,  Yutaka Takahashi,  Kenichi Takahashi,  Fyodor N Zolotaryov,  Kyoung Su Hong,  Riko Kitazawa,  Keiji Iida,  Yasuhiko Okimura,  Hidesuke Kaji,  Sohei Kitazawa,  Masato Kasuga,  Kazuo Chihara
Affiliations

Affiliation

  • 1 Division of Diabetes, Metabolism and Endocrinology, Department of Internal Medicine, Kobe University Graduate School of Medicine, Kobe, Japan.
PMID: 18242188 DOI: 10.1016/j.febslet.2008.01.023
Abstract

To explore a novel adipokine, we screened adipocyte differentiation-related gene and found that TIG2/chemerin was strongly induced during the adipocyte differentiation. Chemerin was secreted by the mature 3T3-L1 adipocytes and expressed abundantly in adipose tissue in vivo as recently described. Intriguingly, the expression of chemerin was differently regulated in the liver and adipose tissue in db/db mice. In addition, serum chemerin concentration was decreased in db/db mice. Chemerin and its receptor/ChemR23 were expressed in mature adipocytes, suggesting its function in autocrine/paracrine fashion. Finally, chemerin potentiated insulin-stimulated glucose uptake concomitant with enhanced Insulin signaling in the 3T3-L1 adipocytes. These data establish that chemerin is a novel adipokine that regulates adipocyte function.

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