2. Academic Validation
  3. Antiperoxidation activity of triterpenoids from rhizome of Anemone raddeana

Antiperoxidation activity of triterpenoids from rhizome of Anemone raddeana

  • Fitoterapia. 2009 Mar;80(2):105-11. doi: 10.1016/j.fitote.2008.11.003.
Xin Chen 1,  Jincai Lu,  Wenfei He,  Haidong Chi,  Koichi Yamashita,  Masanobu Manabe,  Hiroyuki Kodama
Affiliations

Affiliation

  • 1 Department of Medicinal Plants, Shenyang Pharmaceutical University, Shenyang, 110016, China.
PMID: 19084054 DOI: 10.1016/j.fitote.2008.11.003
Abstract

Four triterpenoid compounds hederacolchiside E (1), hederasaponin B (2), raddeanoside 20 (3) and raddeanoside 21 (4) were isolated from ethanol extracts of rhizome of Anemone raddeana Regel. The effects of these triterpenoids on superoxide generation, tyrosyl phosphorylation of proteins and translocation of cytosolic compounds, such as p47(phox), p67(phox) and Rac to the cell membrane in human neutrophils was investigated. The superoxide generation induced by N-formyl-methionyl-leucyl-phenylalanine (fMLP) was slightly suppressed by hederasaponin B, raddeanoside 20 and raddeanoside 21 in a concentration dependent manner. The superoxide generation induced by arachidonic acid (AA) was suppressed by hederasaponin B and raddeanoside 21 significantly. fMLP- and AA-induced tyrosyl phosphorylation and translocation of the cytosolic proteins: p47(phox), p67(phox), and Rac to the cell membrane were suppressed in parallel with the suppression of stimulus-induced superoxide generation.

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