2. Academic Validation
  3. Modulating the development of E. coli biofilms with 2-aminoimidazoles

Modulating the development of E. coli biofilms with 2-aminoimidazoles

  • Bioorg Med Chem Lett. 2010 Nov 1;20(21):6310-2. doi: 10.1016/j.bmcl.2010.08.075.
Catherine S Reed 1,  Robert W Huigens 3rd,  Steven A Rogers,  Christian Melander
Affiliations

Affiliation

  • 1 Department of Chemistry, North Carolina State University, Raleigh, NC 27695-8024, United States.
PMID: 20846860 DOI: 10.1016/j.bmcl.2010.08.075
Abstract

The synthesis of a 20 member 2-aminoimidazole/triazole pilot library is reported. Each member of the library was screened for its ability to inhibit or promote biofilm development of either Escherichia coli and Acinetobacter baumannii. From this screen, E. coli-selective 2-aminoimidazoles were discovered, with the best inhibitor inhibiting biofilm development with an IC(50) of 13μM. The most potent promoter of E. coli biofilm formation promoted biofilm development by 321% at 400μM.

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