2. Academic Validation
  3. Opposite effects of endothelin-1 and Big-endothelin-(1-39) on renal function in rats

Opposite effects of endothelin-1 and Big-endothelin-(1-39) on renal function in rats

  • Eur J Pharmacol. 1990 Jul 17;182(3):603-6. doi: 10.1016/0014-2999(90)90064-d.
A Hoffman 1,  E Grossman,  H R Keiser
Affiliations

Affiliation

  • 1 Hypertension-Endocrine Branch, National Heart, Lung and Blood Institute, NIH, Bethesda, MD 20892.
PMID: 2226627 DOI: 10.1016/0014-2999(90)90064-d
Abstract

Bolus injections of Big-endothelin-(1-39) (Big-ET; 0.1-3.0 nmol/kg) induced a dose-dependent diuretic and natriuretic response in conscious Sprague-Dawley rats. Endothelin-1-(1-21) (ET-1; 1 nmol/kg) induced an opposite effect with almost complete renal shut down. Renal blood flow did not change with Big-ET but was reduced by half with ET-1. Although the maximal pressor responses of the two Peptides were comparable the renal resistance did not change with Big-ET but increased 4-fold with ET-1. These data suggest that Big-ET may have a different mechanism of action than ET-1.

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