2. Academic Validation
  3. Total synthesis of nucleoside antibiotic A201A

Total synthesis of nucleoside antibiotic A201A

  • J Am Chem Soc. 2014 Mar 19;136(11):4157-60. doi: 10.1021/ja501460j.
Shenyou Nie 1,  Wei Li,  Biao Yu
Affiliations

Affiliation

  • 1 State Key Laboratory of Bio-organic and Natural Products Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences , Shanghai 200032, China.
PMID: 24611434 DOI: 10.1021/ja501460j
Abstract

A201A, a unique nucleoside Antibiotic with potent Antibacterial activities, has been synthesized for the first time in a total of 47 steps in a highly modular and linear manner, highlighting the elaboration/incorporation of an unprecedented hexofuranoside unit bearing an exocyclic enol ether moiety.

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