2. Academic Validation
  3. The intercellular cell adhesion molecule-1 (icam-1) in lung cancer: implications for disease progression and prognosis

The intercellular cell adhesion molecule-1 (icam-1) in lung cancer: implications for disease progression and prognosis

  • Anticancer Res. 2014 Sep;34(9):4665-72.
Elias A Kotteas 1,  Panagiotis Boulas 1,  Ioannis Gkiozos 1,  Sofia Tsagkouli 1,  George Tsoukalas 1,  Konstantinos N Syrigos 2
Affiliations

Affiliations

  • 1 Oncology Unit GPP, Athens School of Medicine, Sotiria General Hospital, Athens, Greece.
  • 2 Oncology Unit GPP, Athens School of Medicine, Sotiria General Hospital, Athens, Greece [email protected].
PMID: 25202042
Abstract

The intercellular cell-adhesion molecule-1 (ICAM-1) is a transmembrane molecule and a distinguished member of the Immunoglobulin superfamily of proteins that participates in many important processes, including leukocyte endothelial transmigration, cell signaling, cell-cell interaction, cell polarity and tissue stability. ICAM-1and its soluble part are highly expressed in inflammatory conditions, chronic diseases and a number of malignancies. In the present article we present the implications of ICAM-1 in the progression and prognosis of one of the major global killers of our era: lung Cancer.

Keywords

Intercellular cell-adhesion molecule; cell polarity; cell signaling; cell-cell interaction; immunoglobulin; lung cancer; prognosis; review.

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