2. Academic Validation
  3. SnapShot: Interferon Signaling

SnapShot: Interferon Signaling

  • Cell. 2015 Dec 17;163(7):1808-1808.e1. doi: 10.1016/j.cell.2015.12.008.
Kwan T Chow 1,  Michael Gale Jr 1
Affiliations

Affiliation

  • 1 Department of Immunology, Center for Innate Immunity and Immune Disease, University of Washington School of Medicine, 750 Republican Street, Seattle, WA 98109, USA.
PMID: 26687364 DOI: 10.1016/j.cell.2015.12.008
Abstract

Interferons (IFNs) are crucial cytokines of antimicrobial, antitumor, and immunomodulatory activity. The three types of IFN (I, II, and III) are classified by their receptor specificity and sequence homology. IFNs are produced and secreted by cells in response to specific stimuli. Here, we review the subsequent IFN signaling events occurring through unique receptors leading to regulation of gene expression for modulation of innate and adaptive immunity. To view this SnapShot, open or download the PDF.

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