2. Academic Validation
  3. Integrating immunometabolism and macrophage diversity

Integrating immunometabolism and macrophage diversity

  • Semin Immunol. 2016 Oct;28(5):417-424. doi: 10.1016/j.smim.2016.10.004.
Maxim N Artyomov 1,  Alexey Sergushichev 2,  Joel D Schilling 3
Affiliations

Affiliations

  • 1 Department of Pathology & Immunology, Washington University School of Medicine, St. Louis, MO 63110, USA. Electronic address: [email protected].
  • 2 Department of Pathology & Immunology, Washington University School of Medicine, St. Louis, MO 63110, USA; Computer Technologies Department, ITMO University, Saint Petersburg 197101, Russia.
  • 3 Department of Pathology & Immunology, Washington University School of Medicine, St. Louis, MO 63110, USA; Diabetic Cardiovascular Disease Center, Washington University School of Medicine, St. Louis, MO, USA; Department of Medicine, Washington University School of Medicine, St. Louis, MO, USA. Electronic address: [email protected].
PMID: 27771140 DOI: 10.1016/j.smim.2016.10.004
Abstract

Macrophages are heterogeneous cells that play a key role in inflammatory and tissue reparative responses. Over the past decade it has become clear that shifts in cellular metabolism are important determinants of macrophage function and phenotype. At the same time, our appreciation of macrophage diversity in vivo has also been increasing. Factors such as cell origin and tissue localization are now recognized as important variables that influence macrophage biology. Whether different macrophage populations also have unique metabolic phenotypes has not been extensively explored. In this article, we will discuss the importance of understanding how macrophage origin can modulate metabolic programming and influence inflammatory responses.

Keywords

Glycolysis; Inflammation; Metabolism; Mitochondria; Nitric oxide.

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