2. Academic Validation
  3. Interleukin-3 Prevents Cellular Death Induced by Oxidative Stress in HEK293 Cells

Interleukin-3 Prevents Cellular Death Induced by Oxidative Stress in HEK293 Cells

  • J Cell Biochem. 2017 Jun;118(6):1330-1340. doi: 10.1002/jcb.25790.
Camila López 1,  Patricia Zamorano 1,  Stefanie Teuber 1,  Mónica Salas 1,  Carola Otth 2 3,  María A Hidalgo 4,  Ilona Concha 1,  Angara Zambrano 1 3
Affiliations

Affiliations

  • 1 Facultad de Ciencias, Instituto de Bioquímica y Microbiología, Valdivia, Chile.
  • 2 Facultad de Medicina, Instituto de Microbiología Clínica, Valdivia, Los Ríos, Chile.
  • 3 Center for Interdisciplinary Studies on the Nervous System (CISNe), Universidad Austral de Chile, Valdivia, Chile.
  • 4 Facultad de Ciencias Veterinarias, Instituto de Farmacología, Universidad Austral de Chile, Valdivia, Los Ríos, Chile.
PMID: 27862234 DOI: 10.1002/jcb.25790
Abstract

Interleukin-3 (IL-3) is a well-characterized growth factor in hematopoietic cells, but it is also expressed in other cell types with poorly described functions. Many studies have provided evidence that IL-3 plays an important role in cell survival. We have previously shown that IL-3 is able to increase glucose uptake in HEK293 cells, suggesting that this factor requires sustained glucose metabolism to promote cell survival. In this study, we demonstrate that IL-3 contributes to cell survival under oxidative stress, a prominent feature in the pathophysiology of Cancer, diabetes, and neurodegenerative diseases, as well as in the aging process. Our results suggest a molecular mechanism that involves signaling pathways mediated by PI-3k/Akt and ERK. Altogether, these findings show an important role for IL-3 in supporting the viability of non-hematopoietic systems. J. Cell. Biochem. 118: 1330-1340, 2017. © 2016 Wiley Periodicals, Inc.

Keywords

CELL SURVIVAL; Erk; IL-3; OXIDATIVE STRESS; PI3k/Akt.

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