2. Academic Validation
  3. New Prenylated ortho-Dihydroxycoumarins from the Fruits of Ficus nipponica

New Prenylated ortho-Dihydroxycoumarins from the Fruits of Ficus nipponica

  • Chem Biodivers. 2017 Sep;14(9). doi: 10.1002/cbdv.201700196.
Yui Akihara 1,  Emi Ohta 1,  Tatsuo Nehira 2,  Hisashi Ômura 1,  Shinji Ohta 1
Affiliations

Affiliations

  • 1 Graduate School of Biosphere Science, Hiroshima University, 1-7-1 Kagamiyama, Higashi-Hiroshima, 739-8521, Japan.
  • 2 Graduate School of Integrated Arts and Sciences, Hiroshima University, 1-7-1 Kagamiyama, Higashi-Hiroshima, 739-8521, Japan.
PMID: 28574644 DOI: 10.1002/cbdv.201700196
Abstract

Two new prenylated ortho-dihydroxycoumarins, designated fipsomin (1) and fipsotwin (2), were isolated from the fruits of Ficus nipponica together with a known prenylated coumarin, apigravin (3). Their structures were established by spectroscopic data and X-ray crystallographic analysis. Compound 1 exhibited Antibacterial activity against Bacillus subtilis with an MIC value of 61 μm, while 2 and 3 showed very weak activity.

Keywords

Ficus nipponica; Fipsomin; Fipsotwin; Moraceae; Prenylated coumarin.

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