2. Academic Validation
  3. FAM49B, a novel regulator of mitochondrial function and integrity that suppresses tumor metastasis

FAM49B, a novel regulator of mitochondrial function and integrity that suppresses tumor metastasis

  • Oncogene. 2018 Feb 8;37(6):697-709. doi: 10.1038/onc.2017.358.
M S Chattaragada 1 2,  C Riganti 3,  M Sassoe 4,  M Principe 1 2,  M M Santamorena 1 2,  C Roux 1 2,  C Curcio 1 2,  A Evangelista 5,  P Allavena 6,  R Salvia 7,  B Rusev 8,  A Scarpa 8,  P Cappello 1 2 9,  F Novelli 1 2 9
Affiliations

Affiliations

  • 1 Department of Molecular Biotechnology and Health Sciences, University of Turin, Turin, Italy.
  • 2 Center for Experimental Research and Medical Studies, Azienda Universitaria Ospedaliera Città della Salute e della Scienza di Torino, Turin, Italy.
  • 3 Department of Oncology, University of Turin, Turin, Italy.
  • 4 Department of Neurosciences, 'Rita Levi Montalcini', University of Turin, Turin, Italy.
  • 5 Department of Clinical Epidemiology, Azienda Universitaria Ospedaliera Città della Salute e della Scienza and CPO Piemonte, Turin, Italy.
  • 6 Laboratory of Molecular Gastroenterology, Department of Gastroenterology, Humanitas Clinical and Research Center, Milan, Italy.
  • 7 Department of Surgery, The Pancreas Institute, University and Hospital Trust of Verona, Verona, Italy.
  • 8 Department of Pathology and Public Health & ARC-NET Research Center, University and Hospital Trust of Verona, Verona, Italy.
  • 9 Molecular Biotechnology Center, University of Turin, Turin, Italy.
PMID: 29059164 DOI: 10.1038/onc.2017.358
Abstract

Mitochondrial dysregulation plays a central role in cancers and drives Reactive Oxygen Species (ROS)-dependent tumor progression. We investigated the pro-tumoral roles of mitochondrial dynamics and altered intracellular ROS levels in pancreatic ductal adenocarcinoma (PDAC). We identified 'family with sequence similarity 49 member B' (FAM49B) as a mitochondria-localized protein that regulates mitochondrial fission and Cancer progression. Silencing FAM49B in PDAC cells resulted in increased fission and mitochondrial ROS generation, which enhanced PDAC cell proliferation and invasion. Notably, FAM49B expression levels in PDAC cells were downregulated by the tumor microenvironment. Overall, the results of this study show that FAM49B acts as a suppressor of Cancer cell proliferation and invasion in PDAC by regulating tumor mitochondrial redox reactions and metabolism.

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