2. Academic Validation
  3. Inhibitory effect of brain natriuretic peptide on central angiotensin II-stimulated pressor response in conscious rats

Inhibitory effect of brain natriuretic peptide on central angiotensin II-stimulated pressor response in conscious rats

  • Neurosci Lett. 1988 Aug 15;91(1):77-83. doi: 10.1016/0304-3940(88)90252-2.
G Shirakami 1,  K Nakao,  T Yamada,  H Itoh,  K Mori,  K Kangawa,  N Minamino,  H Matsuo,  H Imura
Affiliations

Affiliation

  • 1 Department of Medicine, Kyoto University School of Medicine, Japan.
PMID: 2971901 DOI: 10.1016/0304-3940(88)90252-2
Abstract

The effect of intracerebroventricular injection of brain natriuretic peptide (BNP) on blood pressure and heart rate was studied in conscious, unrestrained rats. The intracerebroventricular (i.c.v.) injection of BNP did not affect basal blood pressure and heart rate, but it attenuated i.c.v. angiotensin II (AII)-induced pressor response in a dose-dependent manner. These results suggest that BNP plays a role in the regulation of blood pressure in the central nervous system.

Figures
Products