An exaggerated epinephrine-adrenergic receptor signaling impairs uterine decidualization in mice

Reprod Toxicol. 2019 Dec;90:109-117. doi: 10.1016/j.reprotox.2019.09.003.

Jinxiang Wu ¹, Shuangbo Kong ², Chuanhui Guo ³, Jianqi Wang ³, Jinhua Lu ², Ruiwei Jiang ⁴, Haibin Wang ⁵

Affiliations

1 The School of Basic Medical Sciences, Fujian Medical University, Fuzhou, People's Republic of China.
2 Reproductive Medical Center, The First Affiliated Hospital of Xiamen University, Xiamen, Fujian, People's Republic of China; Fujian Provincial Key Laboratory of Reproductive Health Research, School of Medicine, Xiamen University, Xiamen, Fujian, People's Republic of China.
3 Fujian Provincial Key Laboratory of Reproductive Health Research, School of Medicine, Xiamen University, Xiamen, Fujian, People's Republic of China.
4 Reproductive Medical Center, The First Affiliated Hospital of Xiamen University, Xiamen, Fujian, People's Republic of China; Fujian Provincial Key Laboratory of Reproductive Health Research, School of Medicine, Xiamen University, Xiamen, Fujian, People's Republic of China. Electronic address: [email protected].
5 The School of Basic Medical Sciences, Fujian Medical University, Fuzhou, People's Republic of China; Reproductive Medical Center, The First Affiliated Hospital of Xiamen University, Xiamen, Fujian, People's Republic of China; Fujian Provincial Key Laboratory of Reproductive Health Research, School of Medicine, Xiamen University, Xiamen, Fujian, People's Republic of China. Electronic address: [email protected].

PMID: 31520687 DOI: 10.1016/j.reprotox.2019.09.003

Abstract

Our understanding of the relationship between stress-derived epinephrine and early pregnancy failure remains incomplete. Here, we explored the effect of epinephrine exposure on early pregnancy and pseudopregnancy in mice. Increased expression of adrenergic receptors Adra1b, Adra2b and Adrb2 was observed during decidualization and post-implantation embryogenesis was delayed or survival impaired. Epinephrine treatment also impaired decidualization in both the gravid and pseudopregnant uterus, suggesting the effect on decidualization was independent of the conceptus. This included a suppression of endometrial stroma cell proliferation and of key decidualization regulators, including COX2, BMP2 and WNT4. Collectively, these data demonstrate that maternal epinephrine exposure during early pregnancy impairs uterine decidualization and embryo development, underlying early pregnancy failure.

Keywords

Decidualization; Epinephrine; Pregnancy failure; Stress.

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