2. Academic Validation
  3. Moringin, A Stable Isothiocyanate from Moringa oleifera, Activates the Somatosensory and Pain Receptor TRPA1 Channel In Vitro

Moringin, A Stable Isothiocyanate from Moringa oleifera, Activates the Somatosensory and Pain Receptor TRPA1 Channel In Vitro

  • Molecules. 2020 Feb 22;25(4):976. doi: 10.3390/molecules25040976.
Gigliola Borgonovo 1,  Luciano De Petrocellis 2,  Aniello Schiano Moriello 2 3,  Simona Bertoli 1,  Alessandro Leone 1,  Alberto Battezzati 1,  Stefania Mazzini 1,  Angela Bassoli 1
Affiliations

Affiliations

  • 1 Department of Food, Environment and Nutrition-DeFENS, University of Milan, Via Celoria 2, I-20133 Milano, Italy.
  • 2 Endocannabinoid Research Group-Institute of Biomolecular Chemistry-CNR, Pozzuoli, I-87078 Napoli, Italy.
  • 3 Epitech Group SpA, Saccolongo, 35030 Padova, Italy.
PMID: 32098328 DOI: 10.3390/molecules25040976
Abstract

Moringa oleifera Lam. is a tropical plant widely used in traditional medicines and as a food supplement. It is characterized by the presence of glucosinolates and isothiocyanates; the stable isothiocyanate 4-[(α-l-rhamnosyloxy)benzyl]isothiocyanate (moringin) has been widely studied for its bioactivity as hypoglycemic, antimicrobial, Anticancer and in particular for its involvement in nociception and neurogenic pain. Moringa extracts and pure moringin were submitted to in vitro assays with the somatosensory TRPA1 ion channel, proving that moringin is a potent and effective agonist of this receptor involved in nociceptive function and pain states. Moringin do not activate or activates very weakly the vanilloids somatosensory channels TRPV1,2,3 and 4, and the melastatin cooling receptor TRPM8. The comparison of moringin's activity with other known agonists of natural origin is also discussed.

Keywords

Moringa oleifera; TRPA1 ion channel; isothiocyanates; moringin.

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