2. Academic Validation
  3. An in vitro and in silico evaluation of bioactive potential of cornelian cherry (Cornus mas L.) extracts rich in polyphenols and iridoids

An in vitro and in silico evaluation of bioactive potential of cornelian cherry (Cornus mas L.) extracts rich in polyphenols and iridoids

  • Food Chem. 2021 Jan 15;335:127619. doi: 10.1016/j.foodchem.2020.127619.
Bojana Blagojević 1,  Dejan Agić 2,  Ana Teresa Serra 3,  Sara Matić 4,  Mihaela Matovina 5,  Sandra Bijelić 6,  Boris M Popović 7
Affiliations

Affiliations

  • 1 Department of Field and Vegetable Crops, Faculty of Agriculture, University of Novi Sad, Trg Dositeja Obradovića 8, 21000 Novi Sad, Serbia. Electronic address: [email protected].
  • 2 Faculty of Agrobiotechnical Sciences Osijek, Josip Juraj Strossmayer University of Osijek, Vladimira Preloga 1, 31 000 Osijek, Croatia. Electronic address: [email protected].
  • 3 Instituto de Tecnologia Química e Biológica António Xavier, Universidade Nova de Lisboa (ITQB NOVA), Oeiras, Portugal; iBET, Instituto de Biologia Experimental e Tecnológica, Apartado 12, Oeiras, Portugal. Electronic address: [email protected].
  • 4 Division of Organic Chemistry and Biochemistry, Ruđer Bošković Institute, Bijenička 54, 10 000 Zagreb, Croatia. Electronic address: [email protected].
  • 5 Division of Organic Chemistry and Biochemistry, Ruđer Bošković Institute, Bijenička 54, 10 000 Zagreb, Croatia. Electronic address: [email protected].
  • 6 Department of Fruit Growing, Viticulture, Horticulture and Landscape Architecture, Faculty of Agriculture, University of Novi Sad, Trg Dositeja Obradovića 8, 21000 Novi Sad, Serbia. Electronic address: [email protected].
  • 7 Department of Field and Vegetable Crops, Faculty of Agriculture, University of Novi Sad, Trg Dositeja Obradovića 8, 21000 Novi Sad, Serbia. Electronic address: [email protected].
PMID: 32739809 DOI: 10.1016/j.foodchem.2020.127619
Abstract

In the present research, seven different cornelian cherry (Cornus mas L.) cultivars and selections were examined. In vitro and in silico methods were applied for determining and correlating phytochemical constituents and biological potential. Loganic acid, cornuside, cyanidin3-galactoside, and pelargonidin 3-galactoside were determined as the most dominant compounds, presenting ≥90% of the all detected iridoid and phenolic constituents in the extracts. Cornelian cherry fruits were characterized by high antioxidant capacity and antiproliferative activity on human colon Cancer cells (HT29). It was observed the strong inhibitory potential of α-amylase, α-glucosidase, and Dipeptidyl Peptidase III (DPP III) Enzyme activities. Principal component analysis (PCA) was used as a very helpful tool to discriminate the constituents with the highest contribution to tested bioactivities and to highlight the most potent genotypes. PCA, together with binding energies measurements and docking analysis, pointed out pelargonidin 3-robinobioside as the strongest inhibitor of α-glucosidase.

Keywords

Antioxidants; Cornelian cherry; Cornus mas; Dipeptidyl peptidase III; HT29; α-Amylase; α-Glucosidase.

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