2. Academic Validation
  3. Lipoprotein-based drug delivery

Lipoprotein-based drug delivery

  • Adv Drug Deliv Rev. 2020;159:377-390. doi: 10.1016/j.addr.2020.08.003.
Sara Busatto 1,  Sierra A Walker 2,  Whisper Grayson 3,  Anthony Pham 2,  Ming Tian 2,  Nicole Nesto 3,  Jacqueline Barklund 3,  Joy Wolfram 4
Affiliations

Affiliations

  • 1 Department of Biochemistry and Molecular Biology, Department of Physiology and Biomedical Engineering, Department of Transplantation, Mayo Clinic, Jacksonville, FL 32224, USA. Electronic address: [email protected].
  • 2 Department of Biochemistry and Molecular Biology, Department of Physiology and Biomedical Engineering, Department of Transplantation, Mayo Clinic, Jacksonville, FL 32224, USA.
  • 3 Department of Biology, University of North Florida, Jacksonville, FL 32224, USA.
  • 4 Department of Biochemistry and Molecular Biology, Department of Physiology and Biomedical Engineering, Department of Transplantation, Mayo Clinic, Jacksonville, FL 32224, USA; Department of Biology, University of North Florida, Jacksonville, FL 32224, USA; Department of Nanomedicine, Houston Methodist Research Institute, Houston, TX 77030, USA. Electronic address: [email protected].
PMID: 32791075 DOI: 10.1016/j.addr.2020.08.003
Abstract

Lipoproteins (LPs) are circulating heterogeneous nanoparticles produced by the liver and intestines. LPs play a major role in the transport of dietary and endogenous lipids to target cells through cell membrane receptors or cell surface-bound lipoprotein Lipase. The stability, biocompatibility, and selective transport of LPs make them promising delivery vehicles for various therapeutic and imaging agents. This review discusses isolation, manufacturing, and drug loading techniques used for LP-based drug delivery, as well as recent applications for diagnosis and treatment of Cancer, atherosclerosis, and other life-threatening diseases.

Keywords

Biocompatible nanoparticles; Chemotherapy; Chylomicrons; Drug delivery; High-density lipoproteins; Low-density lipoproteins; Lymphatic transport; Purification; Synthetic lipoproteins; Very low-density lipoproteins.

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