2. Academic Validation
  3. Discovery of Soluble Epoxide Hydrolase Inhibitors from Chemical Synthesis and Natural Products

Discovery of Soluble Epoxide Hydrolase Inhibitors from Chemical Synthesis and Natural Products

  • J Med Chem. 2021 Jan 14;64(1):184-215. doi: 10.1021/acs.jmedchem.0c01507.
Cheng-Peng Sun 1,  Xin-Yue Zhang 1,  Christophe Morisseau 2,  Sung Hee Hwang 2,  Zhan-Jun Zhang 3,  Bruce D Hammock 2,  Xiao-Chi Ma 1 4
Affiliations

Affiliations

  • 1 Dalian Key Laboratory of Metabolic Target Characterization and Traditional Chinese Medicine Intervention, College (Institute) of Integrative Medicine, College of Pharmacy, Dalian Medical University, Dalian 116044, People's Republic of China.
  • 2 Department of Entomology and Nematology, UC Davis Comprehensive Cancer Center, University of California, Davis, California 95616, United States.
  • 3 State Key Laboratory of Cognitive Neuroscience and Learning, Beijing Normal University, Beijing 100875, People's Republic of China.
  • 4 College of Pharmacy, School of Medicine, Hangzhou Normal University, Hangzhou 311121, People's Republic of China.
PMID: 33369424 DOI: 10.1021/acs.jmedchem.0c01507
Abstract

Soluble Epoxide Hydrolase (sEH) is an α/β hydrolase fold protein and widely distributed in numerous organs including the liver, kidney, and brain. The inhibition of sEH can effectively maintain endogenous epoxyeicosatrienoic acids (EETs) levels and reduce dihydroxyeicosatrienoic acids (DHETs) levels, resulting in therapeutic potentials for cardiovascular, central nervous system, and metabolic diseases. Therefore, since the beginning of this century, the development of sEH inhibitors is a hot research topic. A variety of potent sEH inhibitors have been developed by chemical synthesis or isolated from natural sources. In this review, we mainly summarized the interconnected aspects of sEH with cardiovascular, central nervous system, and metabolic diseases and then focus on representative inhibitors, which would provide some useful guidance for the future development of potential sEH inhibitors.

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