New malonylginsenosides from the fresh fruits of Panax notoginseng

Fitoterapia. 2021 Apr;150:104844. doi: 10.1016/j.fitote.2021.104844.

Zheng-Yi Qu ¹, Yu Zong ², Pei-He Zheng ¹, Yin-Ping Jin ¹, Wei Li ³, He-Cheng Wang ², Ya-Li Li ¹, Ying-Ping Wang ⁴

Affiliations

1 Institute of Special Wild Economic Animals and Plants, Chinese Academy of Agricultural Sciences, Changchun 130112, PR China.
2 School of Life Science and Medicine, Dalian University of Technology. Panjin, 124221, PR China.
3 State Local Joint Engineering Research Center of Ginseng Breeding and Application, Jilin Agriculture University, Changchun 130118, PR China.
4 State Local Joint Engineering Research Center of Ginseng Breeding and Application, Jilin Agriculture University, Changchun 130118, PR China. Electronic address: [email protected].

PMID: 33548359 DOI: 10.1016/j.fitote.2021.104844

Abstract

Four new malonylginsenosides, malonylnotoginsenoside Fe (1), malonylnotoginsenoside Ra₁ (2), malonylgypenoside LXXV (3), and malonylginsenoside Mc (4), together with two known analogues, malonylfloralginsenoside Rc₁ (5) and malonylginsenoside Rc (6), were isolated from the fresh fruits of Panax notoginseng. Their structures were determined by MS and NMR experiments. The anti-proliferative activities of the malonylginsenosides (1-6) against SH-SY5Y human neuroblastoma cell line were evaluated using the MTT assay.

Keywords

Cytotoxicity; Fruits; Malonylginsenosides; NMR; Panax notoginseng.

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