2. Academic Validation
  3. Two new triterpenoids from the leaves of Cyclocarya paliurus (Batalin) Iljinskaja

Two new triterpenoids from the leaves of Cyclocarya paliurus (Batalin) Iljinskaja

  • Nat Prod Res. 2022 Aug;36(15):3938-3944. doi: 10.1080/14786419.2021.1900845.
Yao Liu 1,  Guan-Tao Zheng 1,  Xuan-Xuan Zhang 1 2,  Xian-Tao Zhang 3,  Xu-Lan Shang 4,  Sheng-Zuo Fang 4,  Jian Zhang 2,  Zhi-Qi Yin 1
Affiliations

Affiliations

  • 1 Department of TCMs Pharmaceuticals, School of Traditional Chinese Medicine, China Pharmaceutical University, Nanjing, P.R. China.
  • 2 Laboratory of Translational Medicine, Affiliated Hospital of Integrated Traditional Chinese and Western Medicine, Nanjing University of Chinese Medicine, Nanjing, P.R. China.
  • 3 Nanjing Haijing Pharmaceutical Co., Ltd, Nanjing, P.R. China.
  • 4 College of Forestry, Nanjing Forestry University, Nanjing, P.R. China.
PMID: 33719794 DOI: 10.1080/14786419.2021.1900845
Abstract

Two previously undescribed triterpenoids (1-2), along with thirteen known compounds (3-15) were isolated from a CHCl3-soluble extract of the leaves of Cyclocarya paliurus. Their structures were established on the basis of chemical and spectroscopic approaches. These compounds were assessed for their therapeutic effects on diabetic nephropathy (DN)-evoked fibrosis through High-Glucose and transforming growth factor-β1 (TGF-β1) challenged HK-2 cells. Among them, compounds 3, 5 and 8 could remarkedly decrease the level of fibronectin to relieve DN with 27.66 ± 2.77%, 6.09 ± 0.57% and 17.74 ± 5.83% inhibition rate at 10 μM, 10 μM and 1 μM, respectively.

Keywords

Cyclocarya paliurus; HK-2 cells; fibronectin; fibrosis; flavonoids; triterpenoids.

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