2. Academic Validation
  3. Lanostane triterpenoids from cultivated fruiting bodies of basidiomycete Ganoderma mbrekobenum

Lanostane triterpenoids from cultivated fruiting bodies of basidiomycete Ganoderma mbrekobenum

  • Phytochemistry. 2022 Apr;196:113075. doi: 10.1016/j.phytochem.2021.113075.
Arunrat Yangchum 1,  Ryoma Fujii 2,  Wilunda Choowong 1,  Pranee Rachtawee 1,  Maneerat Pobkwamsuk 3,  Thitiya Boonpratuang 3,  Seiji Mori 4,  Masahiko Isaka 5
Affiliations

Affiliations

  • 1 National Center for Genetic Engineering and Biotechnology (BIOTEC), 113 Thailand Science Park, Phaholyothin Road, Klong Luang, Pathumthani, 12120, Thailand.
  • 2 Institute of Quantum Beam Science, Ibaraki University, Mito, 310-8512, Japan.
  • 3 National Biobank of Thailand, 114 Thailand Science Park, Phaholyothin Road, Klong Luang, Pathumthani, 12120, Thailand.
  • 4 Institute of Quantum Beam Science, Ibaraki University, Mito, 310-8512, Japan; Frontier Research Center for Applied Atomic Sciences, Ibaraki University, Tokai, Ibaraki, 319-1106, Japan.
  • 5 National Center for Genetic Engineering and Biotechnology (BIOTEC), 113 Thailand Science Park, Phaholyothin Road, Klong Luang, Pathumthani, 12120, Thailand. Electronic address: [email protected].
PMID: 34974245 DOI: 10.1016/j.phytochem.2021.113075
Abstract

In the quest for medicinally active compounds in mushrooms of the genus Ganoderma, eleven undescribed lanostane triterpenoids, including a novel chlorinated derivative, i.e., (20S,24E)-21-chloro-15β,20,29-trihydroxy-3,7,11-trioxolanosta-8,24-dien-26-oic acid, were isolated from artificially cultivated fruiting bodies of the basidiomycete Ganoderma mbrekobenum. The structures were elucidated on the basis of NMR spectroscopic and mass spectrometry data. The configuration of the C-20 atom in the most abundant 20-hydroxy-lanostane, (20S,24E)-15β,20,29-trihydroxy-3,7,11-trioxolanosta-8,24-dien-26-oic acid, was established by chemical derivatization, and the absolute configuration of the lanostane skeleton was determined by ECD calculation. Two of the undescribed compounds exhibited moderate antimalarial activity.

Keywords

Antimalarial activity; Ganoderma mbrekobenum; Ganodermataceae; Lanostane triterpenoids.

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