2. Academic Validation
  3. Genistein microparticles prepared by antisolvent recrystallization with low-speed homogenization process

Genistein microparticles prepared by antisolvent recrystallization with low-speed homogenization process

  • Food Chem. 2023 May 15:408:135250. doi: 10.1016/j.foodchem.2022.135250.
Xiaonan Zhang 1,  Yan Huang 2,  Hongwei Zhu 3,  Zhiwei Liu 4,  Lubin Zhang 4,  Zhiru Li 3,  Yaqian Niu 5,  Huajiang Zhang 5
Affiliations

Affiliations

  • 1 Jiaying University, Meizhou 514015, China; Guangdong Provincial Key Laboratory of Conservation and Precision Utilization of Characteristic Agricultural Resources in Mountainous Areas, Jiaying University, Meizhou 514015, China; Northeast Agricultural University, Harbin 150030, China; Heilongjiang Xueqin Technology Co., LTD, Harbin 150030, China. Electronic address: [email protected].
  • 2 Jiaying University, Meizhou 514015, China.
  • 3 Northeast Agricultural University, Harbin 150030, China; Heilongjiang Xueqin Technology Co., LTD, Harbin 150030, China.
  • 4 Jiaying University, Meizhou 514015, China; Guangdong Provincial Key Laboratory of Conservation and Precision Utilization of Characteristic Agricultural Resources in Mountainous Areas, Jiaying University, Meizhou 514015, China.
  • 5 Northeast Agricultural University, Harbin 150030, China.
PMID: 36563619 DOI: 10.1016/j.foodchem.2022.135250
Abstract

To create genistein particles, a brand-new antisolvent recrystallization technique was employed. The response surface approach was utilized to optimize the single factor test findings, which were acquired via the preliminary tests. The ideal liquid-to-liquid ratio was 9, the solution concentration was 21 mg/mL, the nozzle diameter was 700 μm, the feed rate was 39.65 mL/min, and the homogenization rate was 1500 rpm. The smallest mean particle size measured was 202.782 nm. SEM was used to study the powder's morphology, while thermal analysis and infrared imaging were used to evaluate its characteristics. The homogeneous antisolvent recrystallization method-prepared GMP has a better dissolving rate and stronger antioxidant activity when compared to genistein powder. The antisolvent recrystallization approach used in this study, which uses low-speed homogenizing instead of conventional grinding and homogenizing, can successfully reduce particle size, improve bioavailability, and use less energy. This topic may thus be made popular because it has real-world applications.

Keywords

Antioxidant activity; Antisolvent; Genistein; Particle size; Powder properties.

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