2. Academic Validation
  3. Hypotensive actions of some analogues of platelet-activating factor (PAF) with higher potencies than natural PAF

Hypotensive actions of some analogues of platelet-activating factor (PAF) with higher potencies than natural PAF

  • Can J Physiol Pharmacol. 1984 Apr;62(4):457-9. doi: 10.1139/y84-073.
Y Kasuya,  Y Masuda,  K Shigenobu
PMID: 6733593 DOI: 10.1139/y84-073
Abstract

Substituents on the nitrogen atom of the phosphorylcholine moiety of natural C16 platelet-activating factor (PAF) were modified or replaced by more bulky groups, and their hypotensive activities were examined with rats. As a result, it was found that N-methylpiperidine and N-methylpyrrolidine analogues were 3-10 times more potent than natural C16-PAF.

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