2. Academic Validation
  3. DNAM-1, a novel adhesion molecule involved in the cytolytic function of T lymphocytes

DNAM-1, a novel adhesion molecule involved in the cytolytic function of T lymphocytes

  • Immunity. 1996 Jun;4(6):573-81. doi: 10.1016/s1074-7613(00)70060-4.
A Shibuya 1,  D Campbell,  C Hannum,  H Yssel,  K Franz-Bacon,  T McClanahan,  T Kitamura,  J Nicholl,  G R Sutherland,  L L Lanier,  J H Phillips
Affiliations

Affiliation

  • 1 DNAX Research Institute of Molecular and Cellular Biology, Department of Human Immunology, Palo Alto, California 94304-1104, USA.
PMID: 8673704 DOI: 10.1016/s1074-7613(00)70060-4
Abstract

Intercellular adhesion molecules play an important role in the generation of T lymphocyte-mediated immune responses. Here, we describe a novel accessory molecule, DNAX accessory molecule-1 (DNAM-1), that is constitutively expressed on the majority of peripheral blood T lymphocytes. DNAM-1 is a 65 kDa transmembrane glycoprotein consisting of 318 aa including two immunoglobulin-like domains. Anti-DNAM-1 monoclonal antibody (MAb) inhibits T and NK cell-mediated cytotoxicity against a variety of tumor cell targets and blocks cytokine production by alloantigen-specific T cells. In addition, DNAM-1 is a tyrosine-phosphorylated signal-transducing molecule that participates in primary adhesion during cytotoxic T lymphocyte (CTL)-mediated cytotoxicity.

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