Nav1.8-IN-9

Cat. No.: HY-160590: FAQs
Data Sheet Handling Instructions

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Nav1.8-IN-9 (Example 16) is an orally active, potent Nav1.8 inhibitor with an IC₅₀ of 0.084 nM. Nav1.8-IN-9 has the potential for widespread pain research.

For research use only. We do not sell to patients.

Nav1.8-IN-9 Chemical Structure

CAS No. : 2966089-14-3

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Purity & Documentation
References
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Description

Nav1.8-IN-9 (Example 16) is an orally active, potent Nav1.8 inhibitor with an IC₅₀ of 0.084 nM. Nav1.8-IN-9 has the potential for widespread pain research^[1].

IC₅₀ & Target^[1]

Nav1.8

0.084 nM (IC₅₀)

In Vivo

Nav1.8-IN-9 (Example 16; 30 mg/kg; a single oral administration) can inhibit mechanical hypersensitivity induced by postoperative pain models in rats for 1 hour, 2 hours, and 4 hours^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

496.48

Formula

C₂₂H₂₀F₄N₄O₃S

CAS No.

2966089-14-3

SMILES

O=C(C1=CC2=C(N=C1N3CCCC(F)(CC3)F)C=C(F)C(F)=C2)NC4=CC=CC(S(=O)(N)=O)=C4

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Solvent & Solubility

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

In Vivo:

The following protocol is derived from the literature and is for reference only. It is recommended to first try a small sample.

Protocol 1

5％ DMSO + 30％ Solutol HS15 + 65％注射用水配置成 3mg/mL 溶液，按照 10mL/kg 灌胃体积给药，给药剂量为 30 mg/kg^[1]。

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

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(per animal)

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(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Ting Liu, et al. Aromatic paracyclic Nav1.8 inhibitors and their applications. CN116462662A.

Nav1.8-IN-9 Related Classifications

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Nav1.8-IN-92966089-14-3Sodium ChannelNa channelsNa+ channelsOrallyNav1.8painInhibitorinhibitorinhibit

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