1. Recombinant Proteins
  2. Receptor Proteins
  3. Enzyme-linked receptors
  4. R1/R6 RPTPs

Tyrosine phosphatase receptors (RPTPs), as known as receptor-like tyrosine phosphatasesor receptor protein tyrosine phosphatases, are a family of integral cell surface proteins that possess intracellular PTP activity and extracellular domains that have sequence homology to cell adhesion molecules. RPTPs consist of a single transmembrane spanning domain, variable N-terminal extracellular regions (ECDs) and either a single or tandem intracellular phosphatase domain. Based on sequence features of their ECDs, the RPTP family can be grouped into 8 sub-families: R1/R6; R2A; R2B; R3; R4; R5; R7; and R8. RPTPs are enzymatic and functional counterparts of RPTKs and initiate intracellular tyrosine phosphorylation-dependent signal transduction in response to binding of extracellular ligands, such as growth factors and cytokines. They are involved in various aspects of cellular functions, such as proliferation, differentiation, survival, migration, and metabolism. Type R1/6 RPTPs subfamily contains a single fibronectin type III domain (FNIII) extracellularly and two cytoplasmic phosphatase domains. CD45 is the first RPTP to be identified based on the sequence homology of its PTP domain and is the only member of R1/R6 subfamily. Variable splicing of three exons in the N-terminal region of CD45 is responsible for a number of CD45 isoforms, whose expressions are cell type-specific and dependent on the stage of cellular differentiation and activation.

Cat. No. Product Name / Synonyms Species Source
  • HY-P7887
    CD45 Protein, Human (552a.a, HEK293, His)

    rHuReceptor-type tyrosine-protein phosphatase C/CD45, His; B220; CD45 antigen; CD45; CD45R; LCA; L-CA; LY5; protein tyrosine phosphatase, receptor type, C; PTPRC; receptor-type tyrosine-protein phosphatase C

    Human HEK 293
    CD45 Protein, Human (HEK 293, His) is a type 1 transmembrane protein tyrosine phosphatase (PTPase) expressed by all the haematopoietic stem cells (HSCs) except that of erythrocytes and platelets.
  • HY-P7884
    CD45 Protein, Mouse (HEK293, His)

    rMuReceptor-type tyrosine-protein phosphatase C/CD45, His; B220; CD45 antigen; CD45; CD45R; LCA; L-CA; LY5; protein tyrosine phosphatase, receptor type, C; PTPRC; receptor-type tyrosine-protein phosphatase C

    Mouse HEK 293
    CD45/PTPRC Protein, Mouse (HEK 293, His) expresses in HEK293 with a His tag at the N-terminus. CD45 is a transmembrane glycoprotein, expressed on almost all haematopoietic cells except for mature erythrocytes. PTPRC is an essential regulator of T and B cell antigen receptor-mediated activation.
  • HY-P72913
    CD45 Protein, Human (HEK293, Fc)

    Receptor-type tyrosine-protein phosphatase C; L-CA; T200; PTPRC; CD45

    Human HEK293
  • HY-P72914
    CD45 Protein, Mouse (sf9)

    Receptor-type tyrosine-protein phosphatase C; L-CA; T200; PTPRC; CD45

    Mouse Sf9 insect cells
  • HY-P72915
    CD45 Protein, Mouse (sf9, His-GST)

    Receptor-type tyrosine-protein phosphatase C; L-CA; T200; PTPRC; CD45

    Mouse Sf9 insect cells
  • HY-P72916
    CD45 Protein, Mouse (HEK293, Fc)

    Receptor-type tyrosine-protein phosphatase C; L-CA; T200; PTPRC; CD45

    Mouse HEK293
  • HY-P74290
    CD45 Protein, Human (HEK293, His)

    Receptor-type tyrosine-protein phosphatase C; L-CA; T200; PTPRC; CD45

    Human HEK293
  • HY-P7888
    PTPRC/CD45R0 Protein, Human (HEK293, His)

    rHuReceptor-type tyrosine-protein phosphatase C/ CD45R0, His; B220; CD45 antigen; CD45; CD45R; LCA; L-CA; LY5; protein tyrosine phosphatase, receptor type, C; PTPRC; receptor-type tyrosine-protein phosphatase C; CD45R0

    Human HEK 293
    PTPRC/CD45R0 Protein, Human (HEK 293, His) expresses in HEK293 with a His tag at the N-terminus. CD45R0 (UCHL1), a member of leucocyte common antigen family, is expressed largely on previously activated or memory T cells.
  • HY-P7889
    PTPRC/CD45RA Protein, Human (HEK293, His)

    rHuReceptor-type tyrosine-protein phosphatase C/CD45RA, His ; B220; CD45 antigen; CD45; CD45R; LCA; L-CA; LY5; protein tyrosine phosphatase, receptor type, C; PTPRC; receptor-type tyrosine-protein phosphatase C

    Human HEK 293
Cat. No. Product Name Effect Purity