Liver cancer can be classified into primary liver cancer and secondary liver cancer. Secondary liver cancer is the metastatic liver cancer. Primary liver cancer includes hepatocellular carcinoma (HCC), intrahepatic cholangiocarcinoma (ICC) and fibrolamellar HCC, of which HCC is the most common form, accounting for approximately 90% of primary liver cancers[1]. HCC mouse models include chemical agent-induced models, transplanted tumor models, and genetic engineered models.
Liver Cancer Modeling
Liver cancer modeling is an experimental process used to study and simulate the occurrence, development, and treatment of liver cancer. Commonly used liver cancer models include chemical induction, gene editing, patient-derived transplant models, patient-derived tumor models, etc. These models may provide a platform to understand liver cancer biology and evaluate potential therapeutic strategies. The chemical induction model induces liver cancer by giving animals carcinogens, and the gene editing model simulates liver cancer mutations by changing key genes. Liver cancer modeling provides an important tool for tumor biology research and drug development.
Related Experimental Schemes
