1. GPCR/G Protein
  2. Bombesin Receptor
  3. RC-3095 acetate

RC-3095 acetate 

Cat. No.: HY-P0107B
Handling Instructions

RC-3095 acetate is a bombesin/gastrin releasing peptide receptor (GRPR) antagonist. RC-3095 acetate exerts protective effects by reducing gastric oxidative injury in the arthritic mice.

For research use only. We do not sell to patients.

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RC-3095 acetate Chemical Structure

RC-3095 acetate Chemical Structure

CAS No. : 162666-31-1

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Description

RC-3095 acetate is a bombesin/gastrin releasing peptide receptor (GRPR) antagonist[1]. RC-3095 acetate exerts protective effects by reducing gastric oxidative injury in the arthritic mice[2].

IC50 & Target

Bombesin receptor; GRPR[1]

In Vivo

RC-3095 impairs aversive but not recognition memory in Wistar male rats[1].
RC-3095 (0.3 mg/kg or 1 mg/kg; S.C.) shows anti-inflammatory effects in 2 experimental models of arthritis, collagen-induced arthritis (CIA) and antigen-induced arthritis (AIA)[2].
Arthritic mice treated with RC-3095 show a significant reduction in the concentrations of IL-17, IL-1 , and TNF, and showed a diminished expression of GRPR[2].

Animal Model: Male Balb/c wild-type mice (weighing 18-25 gm) with AIA model; Male DBA/1J inbred mice (weighing 18-25 gm) with CIA model[2]
Dosage: 1 mg/kg for AIA studies; 0.3 mg/kg or 1 mg/kg for CIA studies
Administration: Injected SC twice a day for a total of 2 or 10 days for AIA studies; Administered SC twice a day for 10 days after the onset of the disease for CIA studies
Result: Reduced neutrophil migration, mechanical hy pernociception, and proteoglycan loss in mice with AIA;
Led to a significant reduction in arthritis clinical scores and the severity of disease in the CIA model.
Molecular Weight

1166.37

Formula

C₅₈H₈₃N₁₅O₁₁

CAS No.

162666-31-1

Sequence

Xaa-Gln-Trp-Ala-Val-Gly-His-Leu-Leu-NH2

Sequence Shortening

XQWAVGHLL-NH2

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

References
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Keywords:

RC-3095RC3095RC 3095Bombesin ReceptorbombesingastrinGRPRprotectiveeffectsgastricoxidativeinjuryarthriticInhibitorinhibitorinhibit

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RC-3095 acetate
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HY-P0107B
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