ABCB8 Protein, Human (Cell-Free, His, SUMO)

ABCB8 is the ATP-binding subunit of mitochondrial potassium channels and cooperates with CCDC51/MITOK to form mitoK (ATP) channels in the inner mitochondrial membrane. This complex promotes ATP-dependent potassium currents. ABCB8 Protein, Human (Cell-Free, His, SUMO) is the recombinant human-derived ABCB8 protein, expressed by E. coli Cell-free , with N-6*His, N-SUMO labeled tag. The total length of ABCB8 Protein, Human (Cell-Free, His, SUMO) is 656 a.a., with molecular weight of 87 kDa.

ABCB8 is the ATP-binding subunit of the mitochondrial potassium channel situated in the mitochondrial inner membrane. Teaming up with CCDC51/MITOK, it forms a protein complex localized within the mitochondria, orchestrating ATP-dependent potassium currents across the inner membrane, known as the mitoK(ATP) channel. Beyond its role in channel activity, ABCB8 is implicated in mitochondrial iron transport. It is essential for preserving normal cardiac function, potentially influencing mitochondrial iron export and regulating the maturation of cytosolic iron-sulfur cluster-containing enzymes (By similarity). Notably, the channel activity is inhibited by ATP through the ABCB8/MITOSUR subunit.

Human

E. coli Cell-free

N-6*His;N-SUMO

Q9NUT2 (G38-H693)

11194

GKTGQLHKAEGEYSDGYRSSSLLRAVAHLRSQLWAHLPRAPLAPRWSPSAWCWVGGALLGPMVLSKHPHLCLVALCEAEEAPPASSTPHVVGSRFNWKLFWQFLHPHLLVLGVAVVLALGAALVNVQIPLLLGQLVEVVAKYTRDHVGSFMTESQNLSTHLLILYGVQGLLTFGYLVLLSHVGERMAVDMRRALFSSLLRQDITFFDANKTGQLVSRLTTDVQEFKSSFKLVISQGLRSCTQVAGCLVSLSMLSTRLTLLLMVATPALMGVGTLMGSGLRKLSRQCQEQIARAMGVADEALGNVRTVRAFAMEQREEERYGAELEACRCRAEELGRGIALFQGLSNIAFNCMVLGTLFIGGSLVAGQQLTGGDLMSFLVASQTVQRSMANLSVLFGQVVRGLSAGARVFEYMALNPCIPLSGGCCVPKEQLRGSVTFQNVCFSYPCRPGFEVLKDFTLTLPPGKIVALVGQSGGGKTTVASLLERFYDPTAGVVMLDGRDLRTLDPSWLRGQVVGFISQEPVLFGTTIMENIRFGKLEASDEEVYTAAREANAHEFITSFPEGYNTVVGERGTTLSGGQKQRLAIARALIKQPTVLILDEATSALDAESERVVQEALDRASAGRTVLVIAHRLSTVRGAHCIVVMADGRVWEAGTH

87 kDa

Greater than 90% as determined by reducing SDS-PAGE.

<1 EU/μg, determined by LAL method.