ABCD3 Protein, Human (Cell-Free, His)

ABCD3 is a member of the ATP-binding cassette (ABC) family. ABCD3 Protein, Human (Cell-Free, His) is the recombinant human-derived ABCD3 protein, expressed by E. coli Cell-free , with N-10*His labeled tag. The total length of ABCD3 Protein, Human (Cell-Free, His) is 659 a.a., with molecular weight of 81.5 kDa.

ABCD3, a member of the ATP-binding cassette (ABC) family, serves as a versatile ATP-dependent transporter with broad substrate specificity, facilitating the transport of various metabolites, including long-chain fatty acids (LCFA)-CoA, dicarboxylic acids-CoA, long-branched-chain fatty acids-CoA, and bile acids from the cytosol to the peroxisome lumen for beta-oxidation. This transporter exhibits fatty acyl-CoA thioesterase and ATPase activities, likely contributing to the hydrolysis of fatty acyl-CoAs into free fatty acids before their ATP-dependent transport into peroxisomes. ABCD3's pivotal role in these processes highlights its significance in the regulation of LCFAs and energy metabolism, specifically in the degradation and biosynthesis of fatty acids through beta-oxidation.

Human

E. coli Cell-free

N-10*His

P28288 (M1-S659)

5825

MAAFSKYLTARNSSLAGAAFLLLCLLHKRRRALGLHGKKSGKPPLQNNEKEGKKERAVVDKVFFSRLIQILKIMVPRTFCKETGYLVLIAVMLVSRTYCDVWMIQNGTLIESGIIGRSRKDFKRYLLNFIAAMPLISLVNNFLKYGLNELKLCFRVRLTKYLYEEYLQAFTYYKMGNLDNRIANPDQLLTQDVEKFCNSVVDLYSNLSKPFLDIVLYIFKLTSAIGAQGPASMMAYLVVSGLFLTRLRRPIGKMTITEQKYEGEYRYVNSRLITNSEEIAFYNGNKREKQTVHSVFRKLVEHLHNFILFRFSMGFIDSIIAKYLATVVGYLVVSRPFLDLSHPRHLKSTHSELLEDYYQSGRMLLRMSQALGRIVLAGREMTRLAGFTARITELMQVLKDLNHGKYERTMVSQQEKGIEGVQVIPLIPGAGEIIIADNIIKFDHVPLATPNGDVLIRDLNFEVRSGANVLICGPNGCGKSSLFRVLGELWPLFGGRLTKPERGKLFYVPQRPYMTLGTLRDQVIYPDGREDQKRKGISDLVLKEYLDNVQLGHILEREGGWDSVQDWMDVLSGGEKQRMAMARLFYHKPQFAILDECTSAVSVDVEGYIYSHCRKVGITLFTVSHRKSLWKHHEYYLHMDGRGNYEFKQITEDTVEFGS

81.5 kDa

Greater than 90% as determined by reducing SDS-PAGE.

<1 EU/μg, determined by LAL method.